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Cancer research

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RBM5: potential drug target for acute myeloid leukaemia

15 January 2024 | By Drug Target Review

RBM5 removal from cells meant that HOXA9 mRNA levels were greatly reduced, which could lead to therapies targeting HOXA9-driven leukaemia.

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Blood test developed that reliably detects NEPC

11 January 2024 | By Drug Target Review

A new blood panel test reports the tumour fraction and the tumour type of prostate cancer with a high level of accuracy.

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CBPUV nanoparticles show excellent anticancer activity

10 January 2024 | By Drug Target Review

Novel self-assembled amino acid-based nanoparticles, loaded with doxorubicin, could evolve cancer treatment.

whitepaper

eBook: Modern Microscopy in Cancer Research

10 January 2024 | By Leica Microsystems

Explore the history and trends of microscopy in cancer research and discover the latest cancer imaging solutions and techniques in this eBook.

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Discovery of a previously unknown class of HK-CREs

9 January 2024 | By Drug Target Review

Using bioinformatics analyses, HK-CREs impact on cellular processes was studied, including their potential as housekeeping tumour suppressors.

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Advancing the development of CTLA-4 inhibitors

8 January 2024 | By Drug Target Review

A new study could result in CTLA-4 inhibitors that promote antitumour responses without causing intestinal diseases, such as colitis.

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Controlling MYC’s hyperactivity with a peptide compound

8 January 2024 | By Drug Target Review

A novel peptide can suppress MYC by binding directly to it with sub-micro-molar affinity, advancing cancer drug development.

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Allosteric control sites in KRAS protein found

5 January 2024 | By Ellen Capon (Drug Target Review)

The first complete control map for any protein has been made for KRAS, and four potential drug targets have been discovered.

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Discovery enables further investigation into new ligases

4 January 2024 | By Drug Target Review

Researchers have developed a new PROTAC that activates the protein degradation system and binds to a previously inaccessible ligase.

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Targets for pancreatic cancer treatment found

2 January 2024 | By Drug Target Review

Using tumour organoids, researchers have found a starting point for the development of a more refined PDAC drug.

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Not all neoantigens are created equal

28 December 2023 | By Dr Sergio Quezada (Achilles Therapeutics)

Founder and CSO of Achilles Therapeutics Dr Sergio Quezada reveals how the landmark TRACERx study has gleaned key insights that could make the difference between success and failure in immunotherapy treatment.

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The potential of CD24 in cancer immunotherapy

27 December 2023 | By Dr Roy Maute (Pheast Therapeutics)

Cofounder & Chief Scientific Officer of Pheast Therapeutics, Dr Roy Maute, reveals his company’s promising drug candidate and explains why they have focused on their chosen target.

DNA helix colorful genes chromosomes DNA sequence, DNA structure with glow. Science concept background 3d rendering

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How gene regulatory networks maintain FLT3-ITD mutated AML

22 December 2023 | By Drug Target Review

Using shRNA screening enabled researchers to investigate the roles of individual specific factors in maintaining the network found in AML.

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Drug Target Review Immuno-oncology eBook 2023

22 December 2023 | By

Download this eBook for FREE. Explore cutting-edge immuno-oncology insights through exclusive interviews and studies by leading experts in the field.

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New insights about the development of hematopoietic stem cells

21 December 2023 | By Drug Target Review

Understanding the involvement of Nod1 in the development of blood stem cells could greatly improve blood disorder treatments.

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Cancer research