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Cancer research

news

PLK4 inhibition: a new therapeutic for AML

24 January 2024 | By Drug Target Review

PLK4 inhibition could be a novel therapeutic for an acute myeloid leukaemia subtype carrying the TP53 mutation.

news

Advancing personalised medicine with a cholangiocarcinoma model

23 January 2024 | By Drug Target Review

A patient-specific organ-on-a-chip model of cholangiocarcinoma, with its tumour microenvironment, helps to predict therapy response.

news

How PD-1 promotes Merkel cell carcinoma progression

23 January 2024 | By Drug Target Review

Inhibiting mTOR signalling and neutralising mtROS suppressed MCC-PD-1-mediated tumour proliferation in mice.

article

Immuno-oncology innovations redefining cancer treatment in 2024

23 January 2024 | By Dr Espen Basmo Ellingsen (University of Oslo), Taylor Mixides (Drug Target Review)

In this exclusive interview, Dr Espen Basmo Ellingsen, a luminary in cancer immunology, provides insights into the anticipated breakthroughs, collaborative endeavours, and personalised strategies that promise to elevate the effectiveness and durability of immuno-oncology interventions.

news

Knockdown of FAM3C inhibits breast cancer tumour growth

22 January 2024 | By Drug Target Review

Inhibition of FAM3C expression in cancer-associated adipocytes during early tumour development holds promise as a novel treatment approach.

news

New algorithm can predict when cancer will resist chemotherapy

19 January 2024 | By Drug Target Review

The ML algorithm explores how genetic mutations collectively influence a tumour’s reaction to drugs impeding DNA replication.

article

Using proteomics to overcome glioblastoma resistance

17 January 2024 | By Ellen Capon (Drug Target Review)

Using an AI algorithm to predict glioblastoma’s most active kinase, researchers hope for a next-generation precision therapy targeting resistant cancers.

news

How breast cancer cells take advantage of the extracellular matrix

17 January 2024 | By Drug Target Review

Researchers discover a key metabolic process that cancer cells use to grow in a nutrient deprived environment, which could be a new target.

article

Transforming cancer treatment for greatest impact

15 January 2024 | By Dr Lev Becker (Onchilles Pharma)

In this Q&A, Dr Lev Becker, Associate Professor, University of Chicago and Cofounder of Onchilles Pharma, reveals how his company is directing research into neutrophil biology to the advantage of cancer patients that need it most.

news

RBM5: potential drug target for acute myeloid leukaemia

15 January 2024 | By Drug Target Review

RBM5 removal from cells meant that HOXA9 mRNA levels were greatly reduced, which could lead to therapies targeting HOXA9-driven leukaemia.

news

Blood test developed that reliably detects NEPC

11 January 2024 | By Drug Target Review

A new blood panel test reports the tumour fraction and the tumour type of prostate cancer with a high level of accuracy.

news

CBPUV nanoparticles show excellent anticancer activity

10 January 2024 | By Drug Target Review

Novel self-assembled amino acid-based nanoparticles, loaded with doxorubicin, could evolve cancer treatment.

whitepaper

eBook: Modern Microscopy in Cancer Research

10 January 2024 | By Leica Microsystems

Explore the history and trends of microscopy in cancer research and discover the latest cancer imaging solutions and techniques in this eBook.

news

Discovery of a previously unknown class of HK-CREs

9 January 2024 | By Drug Target Review

Using bioinformatics analyses, HK-CREs impact on cellular processes was studied, including their potential as housekeeping tumour suppressors.

news

Advancing the development of CTLA-4 inhibitors

8 January 2024 | By Drug Target Review

A new study could result in CTLA-4 inhibitors that promote antitumour responses without causing intestinal diseases, such as colitis.

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Cancer research