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Cancer research

news

Novel compound for targeted alpha therapy

4 September 2024 | By Drug Target Review

NpG-D-PSMA has shown great potential for targeted alpha therapy to combat prostate cancer.

news

Pancreatic cancer suppressed by humanised anti-CKAP4 antibody

29 August 2024 | By Drug Target Review

The humanised antibody, Hv1Lt1, showed promising results in pancreatic cancer mouse models.

article

Advancing CAR-T therapy: how CD5 modulation is shaping cancer treatment

29 August 2024 | By Marco Ruella (Vittoria Biotherapeutics), Nicholas Siciliano (Vittoria Biotherapeutics)

Vittoria Biotherapeutics is pioneering a novel form of CAR-T therapy for T-cell lymphoma using CRISPR gene editing. Here, co-founders Nicholas Siciliano and Marco Ruella explain how their approach promises to overcome tumour resistance, while also offering hope for new ways to treat solid cancers.

podcasts

Combatting disease with antibody drug conjugates

27 August 2024 | By Drug Target Review

Tune into this episode where we investigate how antibody drug conjugates can be optimised, as well as the future of the field.

news

Ketogenic diet and a new cancer drug starves pancreatic cells

16 August 2024 | By Drug Target Review

The discovery that eFT508 blocks eIF4E and the ketogenic pathway could provide the foundation for personalised therapies.

news

Genetic variants influencing SR B-ALL relapse risk identified

13 August 2024 | By Drug Target Review

Genome and transcriptome sequencing revealed that subtypes such as TCF3/4::HLF were associated with an increased risk of relapse.

news

Melanoma: predicting immunotherapy-induced side effects

12 August 2024 | By Drug Target Review

Increased gene activity in the SYK pathway could be the basis of a blood test to identify melanoma patients most susceptible to severe side effects.

news

Type 1 regulatory cells limit immunotherapy success

8 August 2024 | By Drug Target Review

Scientists discovered the number of Tr1 cells increased as tumours grew larger, making mice insensitive to immunotherapy.

news

Prostate cancer: delaying resistance to hormone therapy

7 August 2024 | By Drug Target Review

Researchers have developed a new form of immunotherapy that could provide a longer life expectancy to men with prostate cancer.

news

Elucidating MDLC’s molecular features

30 July 2024 | By Drug Target Review

The study’s results indicate that spatial sequencing of mixed-type breast cancers could inform personalised treatment.

news

Treating HCC with genetically modified NK-cell therapy

19 July 2024 | By Drug Target Review

Blocking the TGF-β signalling pathway produced effective antitumour activity against hepatocellular carcinoma.

article

Liquid biopsy helps advance oncology drug development

18 July 2024 | By Dr Chris Haqq (Elicio Therapeutics)

In this exclusive interview with Elicio Therapeutics, we explore the transformative potential of liquid biopsy in oncology drug development, particularly spotlighting its application in Elicio’s AMPLIFY-201 study of ELI-002, a promising therapeutic cancer vaccine candidate.

news

Overcoming chemotherapy resistance in pancreatic cancer

10 July 2024 | By Drug Target Review

Researchers have discovered that pancreatic cancer’s resistance to chemotherapy is related to the physical stiffness of the extracellular matrix.

article

How MMR-deficient colorectal cancers regulate their growth

9 July 2024 | By Ellen Capon (Drug Target Review)

Understanding how MMR-deficient colorectal cancers drive tumour growth and avoid immune detection could pave the way for personalised cancer medicine.

news

Predicting pancreatic cancer metastasis

2 July 2024 | By Drug Target Review

Molecular, cellular and metabolic analyses of liver biopsies identified markers that may predict subsequent metastasis of pancreatic cancer.

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Cancer research