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Cancer research

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How the DA subtype of Wilms tumour resists chemotherapy

5 February 2024 | By Drug Target Review

Researchers suggest that DA histology slowly emerges by accumulating burdens of DNA damage and copy number aberrations.

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Application Note: Understanding The Multiplex Imaging Landscape

1 February 2024 | By Leica Microsystems

Learn about the different types of multiplexed imaging available, as well as their applications, benefits and disadvantages.

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Application note: In situ identification of cancer stem cell niches (HCC)

1 February 2024 | By Leica Microsystems

This app note explores a groundbreaking multiplex immunodetection approach to identify cancer stem cell niches within hepatocellular carcinoma (HCC).

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Augmenting cancer immunogenicity through MHC class I

31 January 2024 | By Drug Target Review

A novel technology can reduce tumour sizes significantly and improve treatment efficacy when used with existing immunotherapy.

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Improving cancer treatment by exploiting mtDNA mutations

30 January 2024 | By Drug Target Review

For the first time, mitochondrial DNA mutations could be used with immunotherapy to increase the chances of successful treatments.

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Targeting Ku70 could improve bowel cancer treatment

29 January 2024 | By Drug Target Review

The Ku70 protein prevents cancer cells from becoming more aggressive and metastasising. It could also be used as an immune biomarker.

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Beyond the lab: stem cell research

29 January 2024 | By Drug Target Review

Download this report to discover more about human derived induced pluripotent stem cells (hiPSCs), the suitability of NK cells for cancer therapy and the latest research into Alzheimer’s disease.

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Therapeutic peptide developed for triple-negative breast cancer

25 January 2024 | By Ellen Capon (Drug Target Review)

Scientists demonstrate how disrupting the Cx26 molecular complex in triple-negative breast cancer cells slowed tumour growth.

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New immunological pathway to treat bone tumours

25 January 2024 | By Drug Target Review

Researchers observed significant upregulation of Siglec-15 in the tumour microenvironment in bone tumour samples from breast cancer patients.

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The potential of PD-L2 inhibitors for cancer treatment

24 January 2024 | By Drug Target Review

Researchers discover that blocking PD-L2 in senescent cells increases the efficacy of chemotherapy in mouse models.

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PLK4 inhibition: a new therapeutic for AML

24 January 2024 | By Drug Target Review

PLK4 inhibition could be a novel therapeutic for an acute myeloid leukaemia subtype carrying the TP53 mutation.

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Advancing personalised medicine with a cholangiocarcinoma model

23 January 2024 | By Drug Target Review

A patient-specific organ-on-a-chip model of cholangiocarcinoma, with its tumour microenvironment, helps to predict therapy response.

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How PD-1 promotes Merkel cell carcinoma progression

23 January 2024 | By Drug Target Review

Inhibiting mTOR signalling and neutralising mtROS suppressed MCC-PD-1-mediated tumour proliferation in mice.

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Immuno-oncology innovations redefining cancer treatment in 2024

23 January 2024 | By Dr Espen Basmo Ellingsen (University of Oslo), Taylor Mixides (Drug Target Review)

In this exclusive interview, Dr Espen Basmo Ellingsen, a luminary in cancer immunology, provides insights into the anticipated breakthroughs, collaborative endeavours, and personalised strategies that promise to elevate the effectiveness and durability of immuno-oncology interventions.

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Knockdown of FAM3C inhibits breast cancer tumour growth

22 January 2024 | By Drug Target Review

Inhibition of FAM3C expression in cancer-associated adipocytes during early tumour development holds promise as a novel treatment approach.

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Cancer research