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Under the microscope with Labcyte
Dr Sheraz Gul, Head of Assay Development and Screening at the Fraunhofer Institute for Molecular Biology and Applied Ecology, answers questions on assay procedures...
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Cell-based assays
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Assays In-Depth Focus 2017
HTS can be carried out in a number of formats, ranging from simple biochemical (target-based) to whole animal screening assay formats. Horst Flotow, from Hit Discovery Constance, discusses the benefits and practicalities of, and recent progress in, whole animal screening. Madhu Lal-Nag, National Center for Advancing Translational Sciences, and Anton…
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Booklet: InCELL Pulse™ Target Engagement Kinase Reference Set
Monitoring cellular drug permeability and target engagement enables assessment of compound efficacy and confirmation of mode of action. InCELL Pulse target engagement assays provide the ability to confirm compound cell entry and target engagement while overcoming limitations of current target engagement assays...
whitepaper
Application Note: An Easy-to-Use Assay to Measure Target Cell Death by Antibody Dependent Cellular Phagocytosis (ADCP)
With an increasing industry focus on antibody drugs, there is an ever greater need for functional bioassays that interrogate the various mechanisms of action (MOA) for the therapeutic antibody...
whitepaper
Whitepaper: Isolation of stably transfected fluorescent cells with the S3™ Cell Sorter
The S3e Cell Sorter demonstrates its utility in performing high purity sorts of adherent cells that express intercellular florescent proteins...
whitepaper
Whitepaper: InCELL target engagement assays
Monitoring cellular drug penetration and drug-target interaction enables assessment of compound efficacy and confirmation of mode of action...
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Cisbio Bioassays Biomarkers & cytokines – quantify intracellular and released proteins
4 October 2016 | By Cisbio Bioassays
A line of high quality products have been developed, addressing biomarkers to meet the needs of multiple therapeutic areas such as inflammation, oncology, metabolic disease or CNS...
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A picture is worth a thousand endpoints: high-content imaging in drug discovery
Over the past few years several factors in the drug discovery industry have come together to drive an increased interest and subsequent surge in the use of high-content imaging. These include the high costs of attrition in the clinic due to lack of efficacy; increased hurdles and rising costs to…
whitepaper
Whitepaper: Accelerating Biosimilar & Biobetter Drug Development: Ready-to-Use, Cell-Based Assays for Potency and Lot Release Testing
This whitepaper highlights how commercial tools can reduce assay development time and enable a biologic developer to get to market or submission before competitors...
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Assays In-Depth Focus 2016
In this Assays In-Depth Focus: "Finding a cure for neglected tropical diseases with cell-based assays", plus "The relevance of homogeneous radiometric assays in modern drug discovery"...
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DiscoverX PathHunter® Pharmacochaperone Trafficking Assays
23 February 2016 | By DiscoverX Corporation
PathHunter cell-based pharmacotrafficking assays provide a simple and quantitative tool for broad pharmacological characterisation and interrogation of compound function in disease processes associated with protein trafficking and internalization due to protein misfolding...
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DiscoverX PathHunter® Checkpoint Signaling Assays
19 February 2016 | By DiscoverX Corporation
PathHunter® Checkpoint Assays enable screening and potency assays for the development of immunotherapy drugs...
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Finding a cure for neglected tropical diseases with cell-based assays
Neglected tropical diseases pose a significant threat to public health and affect nearly one billion people in tropical and sub-tropical regions throughout the world. There is a pressing need to identify new therapeutics for NTDs and many developed nations are participating in drug discovery efforts...
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DiscoverX PathHunter® Bioassays for Biologics
12 February 2016 | By DiscoverX Corporation
PathHunter® bioassays are cell-based assays that are highly validated, simple, and target specific to support biologics drug development...
news
Registration has now opened for Oxford Global’s 17th Annual Drug Discovery Leaders Summit
13 January 2016 | By Oxford Global
Oxford Global Conferences are proud to present the successful 17th Annual Drug Discovery Leaders Summit and co-located 4th Annual Discovery Chemistry & Drug Design Congress taking place on the 13th & 14th June in Berlin...