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Cell-based assays

surface of several coronavirus particles

news

Novel target could treat both SARS-CoV-2 and other coronaviruses

10 December 2020 | By Hannah Balfour (Drug Target Review)

Scientists shows targeting cholesterol or phosphatidylinositol phosphate (PIP) could be a promising strategy to combat multiple coronaviruses.

cartoon of blue coronavirus particles surrounding pink human lungs - idea of SARS-CoV-2 lung pathology

news

Researchers provide new insights into SARS-CoV-2 lung pathology

3 December 2020 | By Hannah Balfour (Drug Target Review)

The new study shows how SARS-CoV-2 significantly remodels cellular processes in just an hour and identifies potential drug targets and therapeutics for COVID-19.

news

Network modelling reveals a potential new Alzheimer’s therapy

25 November 2020 | By Hannah Balfour (Drug Target Review)

Researchers used integrative network biology analysis to identify the molecular mechanisms that may drive Alzheimer’s and identified a potential therapeutic intervention.

shape of a human brain constructed out of red coronavirus particles

news

SARS-CoV-2 can disrupt the blood-brain barrier, find scientists

2 November 2020 | By Hannah Balfour (Drug Target Review)

Binding of SARS-CoV-2 spike proteins to the brain’s endothelial cells can cause the blood-brain barrier to become leaky, potentially causing the neurological symptoms associated with COVID-19.

SARS-CoV-2 particles infecting a human cell

news

Lysosomes key to coronavirus shedding, finds study

29 October 2020 | By Hannah Balfour (Drug Target Review)

Scientists reveal that coronaviruses de-activate lysosomes before using them to exit infected cells and spread through the body.

heart on an abstract blue scientific background

news

Organs-on-a-chip model for breast cancer drug cardiac toxicity testing

27 October 2020 | By Hannah Balfour (Drug Target Review)

The newly developed chip includes heart and breast cancer tissues and could be used to predict the cardiac toxicity of chemotherapeutic drugs.

red viruses pouring out of pink human cell

news

Approved MS medication inhibits SARS-CoV-2 replication in vitro

5 October 2020 | By Hannah Balfour (Drug Target Review)

Dimethyl fumarate (DMF), a multiple sclerosis (MS) drug, inhibited SARS-CoV-2 replication and the hyper-inflammatory immune response associated with COVID-19.

Ovarian cancer cells forming a cancer spheroid as they grow within the peptide-protein co-assembling material [Credit: Alvaro Mata].

news

Novel tumour spheroids could improve ovarian cancer treatments

5 October 2020 | By Hannah Balfour (Drug Target Review)

Researchers have developed a new self-assembling three-dimensional (3D) ovarian cancer tumour model to recreate the in vitro disease more accurately.

SARS-CoV-2 viral particle next to a single RNA strand

news

Novel RNA-targeting molecule can halt SARS-CoV-2 replication

1 October 2020 | By Hannah Balfour (Drug Target Review)

The C5 compound targets the frameshifting element that allows SARS-CoV-2 to effectively replicate and marks the genome for destruction to stop the infection spreading.

stem cell culture stored in liquid nitrogen

news

Regulating cell plasticity through CDK8 inhibition

29 September 2020 | By Hannah Balfour (Drug Target Review)

Researchers show CDK8 inhibition reduces cell plasticity without damaging cells and suggest their approach could have implications for autoimmunity and oncology.

news

Natural pigment could transform long-term toxicology studies

25 September 2020 | By Victoria Rees (Drug Target Review)

A natural pigment from Monascus purpureus can be used to stain cells and distinguish between live and dead ones in toxicology studies.

SARS-CoV-2 viral particle in crosshares with words 'target locked' above

news

Experimental antiviral AR-12 could be a promising COVID-19 treatment

23 September 2020 | By Hannah Balfour (Drug Target Review)

Scientists have demonstrated that AR-12 can inhibit SARS-CoV-2 replication and are working to initiate clinical trials evaluating the antiviral drug.

SARS-CoV-2 particles entering human cells

news

Could FDA-approved drug heparin prevent SARS-CoV-2 infection?

17 September 2020 | By Hannah Balfour (Drug Target Review)

SARS-CoV-2 entry into human cells is dependent on heparan sulfate and disrupting this interaction using heparin reduces infectivity of the coronavirus, find scientists.

news

Novel antiviral drug candidate blocks SARS-CoV-2 reproduction in cells

16 September 2020 | By Victoria Rees (Drug Target Review)

In human cells, a drug candidate called PF-00835231 has demonstrated success at blocking the reproduction of SARS-CoV-2.

cancer cell in yellow being attacked by white blobs - cancer drug/cell therapy

news

Study identifies potential therapeutic targets for most lethal pancreatic cancer

15 September 2020 | By Hannah Balfour (Drug Target Review)

The detailed analysis of adenosquamous cancer of the pancreas (ASCP) suggested FGFR and RORC were two promising therapeutic targets.

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Cell-based assays