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Gene changes caused by Spike protein could explain long COVID
Scientists have shown that the SARS-CoV-2 Spike protein can initiate gene expression changes, potentially explaining long COVID symptoms.
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Cell Cultures
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Sanguinarine shows promise against triple-negative breast cancer
A new study in cell cultures has shown that the sanguinarine plant compound could be used to treat people with triple-negative breast cancer.
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Scientists call for awareness of unintended mutations from CRISPR
Scientists have said that researchers need to be more aware of unintended mutations to human embryos following CRISPR-Cas9 genome editing.
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Realise the true power of your online, atline and offline biologics data
22 April 2021 | By IDBS
Register today for our on-demand upcoming webinar and discover more on about Polar High-Throughput Process Development (HTPD).
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Brain organoids reveal mechanisms of virus-induced microcephaly
Researchers have shown how different viruses such as HSV-1 and Zika can lead to microcephaly using brain organoids.
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Scientists generate human-monkey chimeric embryos
An international collaboration has led to the development of monkey embryos able to grow with injected human stem cells.
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Method to make cell cultures act more like normal cells discovered
Scientists have shown that culturing cells with a modified serum could allow drugs to be screened for toxicity earlier during research.
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New single-cell transcriptomics method does not put cells under stress
Researchers have created a new single-cell transcriptomics approach that cryopreserves cells, limiting the stress they are put under.
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Article: Defeating COVID-19: The science behind a new ELISA
Discover how a new ELISA against S1-RBD for COVID-19 seroconversion detection can accelerate discovery to facilitate vaccine breakthroughs.
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Application note: Effectiveness of CRISPR‑Cas9 using pools of synthetic crRNAs in high-content analysis screening experiments
In this application note, discover how pools of synthetic crRNAs can produce a phenotype as strong as, or stronger, than any one of the component crRNAs in arrayed CRISPR screening experiments.
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Which CHO cell is the right CHO cell?
Dr Louis Boon offers guidance on how to select the best CHO cell for the upstream bioprocessing of biologics. He also explains how automation can aid monoclonality and why the most efficient approach during the development of biological drugs is to utilise an established cell line platform.
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Scientists develop synthetic cell that grows and divides uniformly
Researchers have created a single-celled synthetic organism able to grow and divide that could be used to produce drugs and detect disease.
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Hydrogel used to revert cancer cells back to cancer stem cells
A new hydrogel has been shown to convert cancer cells to cancer stem cells within 24 hours, in six different human cancer cell line types.
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Drug Target Review – Issue 1 2021
In this issue, find articles discussing how high-throughput experimentation can enhance automated molecular discovery, why bNAbs present a promising COVID-19 treatment and how a novel rhinovirus vaccine was developed. Also included are features on immuno-oncology, cell line development and assays.