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Cell Cultures

news

New technology enables predictive design of engineered human cells

22 February 2021 | By Victoria Rees (Drug Target Review)

Researchers have developed a computer modelling programme that can produce genetic circuits for cellular engineering.

news

Bile duct organoids could be used as cell therapy for regenerative medicine

19 February 2021 | By Victoria Rees (Drug Target Review)

For the first time, scientists have grown bile duct organoids that could repair damaged ducts and livers as a new cell therapy.

news

NAD depletion by IFN sensitises pancreatic cancer to NAMPT inhibition, study shows

19 February 2021 | By Victoria Rees (Drug Target Review)

High IFN signalling in pancreatic tumours are sensitive to NAMPT inhibitors which block a pathway in NAD synthesis, presenting a drug target.

news

D614G Spike mutation makes SARS-CoV-2 up to eight times more infectious

18 February 2021 | By Victoria Rees (Drug Target Review)

A study has shown the D614G mutation in the Spike protein of SARS-CoV-2 makes the coronavirus more transmissible than the original virus from China.

news

New drug combination could combat Diffuse Intrinsic Pontine Glioma

17 February 2021 | By Victoria Rees (Drug Target Review)

The drug combination of difluoromethylornithine and AMXT 1501 has shown success against Diffuse Intrinsic Pontine Glioma in animal models.

whitepaper

ebook: Vaccines in the digital age

11 February 2021 | By IDBS

In this ebook, we’ll see how digitally enabling your organisation can increase capacity and improve vaccine production.

news

CRISPR used to model acute myeloid leukaemia progression

11 February 2021 | By Victoria Rees (Drug Target Review)

CRISPR-Cas9 and stem cell technologies have been used to create a cellular model of acute myeloid leukaemia, revealing therapeutic targets.

whitepaper

Whitepaper: Automated cell culture and screening

8 February 2021 | By Ncardia

This whitepaper describes the automated culturing of hiPSC-derived cells for high-throughput phenotypic screening, using validated phenotypic assays.

news

Novel enterocyte-like cells developed by researchers from stem cells

8 February 2021 | By Victoria Rees (Drug Target Review)

A team has developed enterocyte-like cells from hiPSCs, which can be used to study the absorption of novel oral drugs.

news

Flaw found in lab models used to study human blood-brain barrier

8 February 2021 | By Victoria Rees (Drug Target Review)

Researchers have uncovered a flaw in lab models used to study the human blood-brain barrier and a potential strategy to correct the error.

news

Researchers identify how Zika infects foetuses and a potential drug to prevent it

4 February 2021 | By Hannah Balfour (Drug Target Review)

According to scientists, maternal cells act as a reservoir for Zika, enabling the virus to pass from mother to foetus during pregnancy.

whitepaper

Whitepaper: Why BioPharma Lifecycle Management?

28 January 2021 | By IDBS

In this whitepaper we explore some of the major bottlenecks in the development lifecycle and the current barriers to effective digital transformation.

Graphic of a person breathing in a stream of SARS-CoV-2 viral particles, some going down the throat to the lungs, others going up to the brain - idea of neurological symptoms of COVID-19

news

New database to track neurological symptoms of COVID-19

28 January 2021 | By Hannah Balfour (Drug Target Review)

NeuroCOVID will be a resource of clinical information and biospecimens from people who experience neurological problems associated with SARS-CoV-2 infection.

news

In vitro model could aid the development of fatty liver disease treatments

26 January 2021 | By Hannah Balfour (Drug Target Review)

The patient-derived model of non-alcoholic fatty liver disease (NAFLD) accurately reproduced the complex human metabolic pathways involved in the development of the disease.

webinar

High content screening reveals the phenotypic landscape of intestinal organoid regeneration

21 January 2021 | By Yokogawa Life Innovations

Watch our on-demand webinar and learn how image-based phenotypic screening relies on extraction of multivariate information from cells cultured in a large number of screened conditions. In this webinar, we explore the application of complex and biologically relevant model systems for drug screening, such as small intestinal organoids.

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Cell Cultures