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Cell Cultures

Cell infected with red coronavirus particles

news

3D view of SARS-CoV-2 replication cycle could enable antiviral drug development

24 November 2020 | By Hannah Balfour (Drug Target Review)

Scientists have shown how SARS-CoV-2 induces changes in the architecture of host cells to drive replication and made their data available to all.

alveoli with blue SARS-CoV-2 particles (spiky balls) inside

news

Mini lung organoids replicate COVID-19 pathology in a dish

20 November 2020 | By Hannah Balfour (Drug Target Review)

Scientists developed a new culture technique for alveolospheres which they used to study how alveolar cells respond to SARS-CoV-2 infection.

news

New 3D cell culture method could enable personalised cancer therapies

13 November 2020 | By Victoria Rees (Drug Target Review)

A team has extracted single tumour cells from existing cell lines to create 3D cell cultures that could allow for personalised cancer therapies.

Cell culture plates with orange growth media and a pipette above

news

Cell line development services market to grow at 13.3 percent

12 November 2020 | By Hannah Balfour (Drug Target Review)

Reports suggest the market growth is driven by advances in biotechnology and its applications, as well as COVID-19 research.

robotic hand pipetting from petri dish of organoids next to a clock - idea of automation speeding up organoid development [Credit: Daria Sokol/MIPT Press Office].

news

Researchers accelerate organoid development and selection using algorithm

11 November 2020 | By Hannah Balfour (Drug Target Review)

The semi-automated process enabled researchers to make retinal organoid production and selection nearly four times faster.

news

New bioprocess generates haematopoietic stem and progenitor cells

10 November 2020 | By Victoria Rees (Drug Target Review)

A new single-use, closed-system upstream bioprocess has been developed which enables the production of large number of haematopoietic stem cells and progenitor cells.

news

Protease inhibitor aprotinin shows promise against SARS-CoV-2 in cells

5 November 2020 | By Victoria Rees (Drug Target Review)

Researchers have found that aprotinin, an approved drug for influenza in Russia, combats SARS-CoV-2 in cells.

woman scratching the back of her leg while walking on grass - idea of allergic reaction itching

news

Researchers reveal how allergens may trigger itching

2 November 2020 | By Hannah Balfour (Drug Target Review)

Certain sensory neurons and Substance P are potential drug targets for the development of novel allergy preventions or treatments, according to scientists.

Syringe drawing liquid from a vial labelled 'REMDESIVIR', on a background of abstract SARS-CoV-2 particles [Credit: ffikretow@hotmail.com / Shutterstock.com].

news

Researchers identify a potential remdesivir resistance mechanism in SARS-CoV-2

8 October 2020 | By Hannah Balfour (Drug Target Review)

Exploring how the Ebola virus develops remdesivir resistance has highlighted a mutation that could allow SARS-CoV-2 to do the same.

Ovarian cancer cells forming a cancer spheroid as they grow within the peptide-protein co-assembling material [Credit: Alvaro Mata].

news

Novel tumour spheroids could improve ovarian cancer treatments

5 October 2020 | By Hannah Balfour (Drug Target Review)

Researchers have developed a new self-assembling three-dimensional (3D) ovarian cancer tumour model to recreate the in vitro disease more accurately.

colourful SARS-CoV-2 particles surrounding a body shape with the lungs drawn in red

news

The NF-κB pathway drives fatal inflammation in COVID-19, say scientists

2 October 2020 | By Hannah Balfour (Drug Target Review)

Researchers found that the SARS-CoV-2 infection activates the NF-κB pathway, driving unchecked inflammation that contributes to total organ failure in COVID-19 patients.

SARS-CoV-2 viral particle next to a single RNA strand

news

Novel RNA-targeting molecule can halt SARS-CoV-2 replication

1 October 2020 | By Hannah Balfour (Drug Target Review)

The C5 compound targets the frameshifting element that allows SARS-CoV-2 to effectively replicate and marks the genome for destruction to stop the infection spreading.

SARS-CoV-2 particles entering human cells

news

Could a sphingosine nasal spray prevent COVID-19?

30 September 2020 | By Hannah Balfour (Drug Target Review)

According to a study, the lipid sphingosine can inhibit SARS-CoV-2 infection and could potentially be delivered in a nasal spray to prevent COVID-19 infections.

stem cell culture stored in liquid nitrogen

news

Regulating cell plasticity through CDK8 inhibition

29 September 2020 | By Hannah Balfour (Drug Target Review)

Researchers show CDK8 inhibition reduces cell plasticity without damaging cells and suggest their approach could have implications for autoimmunity and oncology.

news

Natural pigment could transform long-term toxicology studies

25 September 2020 | By Victoria Rees (Drug Target Review)

A natural pigment from Monascus purpureus can be used to stain cells and distinguish between live and dead ones in toxicology studies.

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Cell Cultures