news The NF-κB pathway drives fatal inflammation in COVID-19, say scientists 2 October 2020 | By Hannah Balfour (Drug Target Review) Researchers found that the SARS-CoV-2 infection activates the NF-κB pathway, driving unchecked inflammation that contributes to total organ failure in COVID-19 patients.
news Novel RNA-targeting molecule can halt SARS-CoV-2 replication 1 October 2020 | By Hannah Balfour (Drug Target Review) The C5 compound targets the frameshifting element that allows SARS-CoV-2 to effectively replicate and marks the genome for destruction to stop the infection spreading.
news Could a sphingosine nasal spray prevent COVID-19? 30 September 2020 | By Hannah Balfour (Drug Target Review) According to a study, the lipid sphingosine can inhibit SARS-CoV-2 infection and could potentially be delivered in a nasal spray to prevent COVID-19 infections.
news Regulating cell plasticity through CDK8 inhibition 29 September 2020 | By Hannah Balfour (Drug Target Review) Researchers show CDK8 inhibition reduces cell plasticity without damaging cells and suggest their approach could have implications for autoimmunity and oncology.
news Natural pigment could transform long-term toxicology studies 25 September 2020 | By Victoria Rees (Drug Target Review) A natural pigment from Monascus purpureus can be used to stain cells and distinguish between live and dead ones in toxicology studies.
webinar Next generation strategies for cancer immunotherapy 24 September 2020 | By PerkinElmer During this on-demand webinar, two leading researchers will discuss their innovative approaches to developing novel opportunities for immunotherapy treatments.
whitepaper Webinar series: Considerations for successful CRISPR-based cell line engineering 11 September 2020 | By Horizon Discovery Sign up for free weekly 5-10 min videos from Horizon’s expert cell line engineers to help you improve your CRISPR editing experiments.
video On-demand webinar: Leveraging advances in predesigned synthetic sgRNA for highly functional and specific CRISPR-Cas9 gene knockout 11 September 2020 | By Horizon Discovery This webinar explains how synthetic guide RNAs are stable, eliminate cloning and sequencing steps, and avoid innate immune responses and cytotoxicity.
whitepaper Article: Tips for successful editing in T cells 10 September 2020 | By Horizon Discovery Horizon article on the recipe for success for CRISPR editing in T cells.
whitepaper Article: Common CRISPR pitfalls and how to avoid them 9 September 2020 | By Horizon Discovery This article explains how to plan a gene-editing experiment. How to choose your biological system and what reagents to get for your experimental aim.
whitepaper Application note: Human iPS cells modified with Edit-R™ CRISPR-Cas9 reagents 8 September 2020 | By Horizon Discovery Modify the genome and modulate expression of genes within human iPS cells with Dharmacon™ Edit-R CRISPR reagents.
news Novel alpha-synuclein structures could be the target for future Parkinson’s therapies 24 August 2020 | By Hannah Balfour (Drug Target Review) Researchers observed new structures of alpha-synuclein aggregates in their study exploring how the presence of cell membrane phospholipids impacts protein aggregation.
news Inhibiting sortilin could make pancreatic cancer therapies more effective 21 August 2020 | By Hannah Balfour (Drug Target Review) A study has shown that inhibiting sortilin, a neuroprotein known to have increased expression in cancers, reduces pancreatic cancer invasiveness in vitro.
news Pre-clinical study supports remdesivir as COVID-19 treatment 13 July 2020 | By Hannah Balfour (Drug Target Review) Scientists demonstrated that remdesivir can inhibit SARS-CoV-2 replication in human lung cells and improve lung function in mice with COVID-19.
news Novel bioactive dialysis system improves survival in pigs with acute liver failure 10 July 2020 | By Hannah Balfour (Drug Target Review) The bioreactor-based system incorporates liver cells to perform the detoxifying functions of the liver and was tested on pigs with acute liver failure.
