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Scientists discover a small molecule that halts kidney disease progression
A team of researchers set out to discover the disease pathways of a rare genetic kidney disease and found a compound that stops the disease in its tracks.
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Cell Regeneration
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Scientists visualise structure of key DNA repair component
The ATR protein has been imaged at ‘near-atomic resolution’, providing greater insight into its activation in DNA repair.
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SBP scientists uncover mechanism for blood vessel regeneration
A new study led by researchers at Sanford Burnham Prebys Medical Discovery Institute (SBP) has identified a signalling pathway that is essential for angiogenesis, the growth of new blood vessels from pre-existing vessels.
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The immune system promotes spontaneous heart regeneration
In adult mammal hearts, cardiomyoctyes do not proliferate following damage, like that caused by myocardial infarction.
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Pathways leading to beta cell division identified, may aid diabetes treatment
Pancreatic beta cells help maintain normal blood glucose levels by producing the hormone insulin -- the master regulator of energy (glucose). Impairment and the loss of beta cells interrupts insulin production, leading to type 1 and 2 diabetes.
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Plasticell and Kings College London to collaborate in trials of blood platelet substitute
Over 10 million units of platelets are transfused worldwide each year in one of the most common procedures in clinical medicine. However, platelets derived from human donors can transmit infections and trigger serious immune reactions that eventually render the therapy ineffective (a condition known as alloimmune refractoriness). In addition, since…
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Plasticell to produce red blood cell substitute from pluripotent stem cells
Over 90 million blood transfusions are carried out worldwide each year and alternative sources to donor-derived blood are being sought to meet rising demand. In addition there is a need to secure a safer supply of blood products, chiefly in developing countries where there is a relatively higher risk of…
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Regenerating bone and cartilage tissues from apple waste
Researchers from UPM and CSIC have employed waste from the agri-food industry to develop biomaterials that are able to act as matrices to regenerate bone and cartilage tissues, which is of great interest for the treatment of diseases related to ageing.
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Tweaking immune response key to combat neurodegeneration
19 October 2016 | By Niamh Louise Marriott, Digital Content Producer
A better understanding of how we could manipulate immune system conditions might aid to develop novel therapies against Alzheimer's, Kizil argues...
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Bone marrow-derived cells reduce recurrent miscarriage in mice
31 August 2016 | By Niamh Louise Marriott, Digital Content Producer
Using a mouse model, the rate of miscarriage was over 20% in the group that was not transplanted with EPCs while the miscarriage rate was only 5% in...
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Snake gene could hold answer to spinal cord regeneration
8 August 2016 | By Instituto Gulbenkian de Ciência
Researchers from the Instituto Gulbenkian de Ciência, Portugal, have discovered that the key controller of trunk, tail and spinal development is the Oct4 gene, one of the essential regulators of stem cells. The team intend to use their data to open new avenues to the study of spinal cord regeneration...
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Mexican salamander holds key to limb regeneration
5 August 2016 | By MDI Biological Laboratory
The ability of animals to regenerate body parts has always fascinated scientists but until the advent of sophisticated tools for genetic and computational analysis, they had no way of studying the genetic machinery that enables regeneration...
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Signalling mechanism for zebrafish fin regeneration identified
4 August 2016 | By Tokyo Institute of Technology
Certain species of amphibians and fish have the remarkable ability to regenerate tissue. Advances in molecular biological analyses have allowed researchers to identify specific molecules and signalling mechanisms involved in tissue regeneration. Fgf signalling is one such key mechanism...