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Using proteomics to predict long-term disability outcomes in MS
Data from protein analyses, combined with data from patient journals, enabled the discovery of proteins that predict disease progression.
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Central Nervous System (CNS)
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Study reveals new insights on brain development through adolescence
According to US researchers, brain maturation follows a sequence that renders youth sensitive to environmental impacts through adolescence.
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New hydrogel stem cell treatment could repair injured brain tissue
The new ‘hybrid’ hydrogel allowed researchers to safely deliver stem cells to the site of a brain injury in mice.
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Measles virus can develop mutations that cause fatal SSPE
Japanese researchers find a new mechanism for how the measles virus can cause a rare but fatal neurological disorder: subacute sclerosing panencephalitis (SSPE).
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New treatment for MS using artificial nerve fibres
Danish researchers undertake a new project that aims to find new forms of treatment for diseases such as MS, which breaks down myelin and nerve fibres, by developing new, artificial nerve fibres
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Improved AAV could cross blood-brain barrier and deliver gene therapies to CNS
A newly developed AAV has shown promise at delivering gene therapies to the brain in mice and non-human primates.
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Drug Target Review Neuroscience ebook 2022
This ebook includes articles on the latest Alzheimer's research on how to potentially target tau and also how new human disease models can enable the development of transformational novel therapeutics.
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Drug Target Review – Issue 3 2022
In this issue are articles on synthetically engineered bacteria to deliver therapeutics, how single-molecule fluorescence resonance energy transfer was used to image GPCRs and a new assay to identify coronavirus drugs. Also included are pieces on vaccine development, monoclonal antibodies and neuroscience.
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Product hub: A reproducible and scalable Huntington’s disease human cell model
Senior scientist Dr Tony Oosterveen discusses bit.bio’s new ioDisease Model portfolio, including new models for Huntington’s disease to help advance in vitro research and drug discovery.
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Driving precision neurology forwards with iPSCs and new assays
Precision medicine in neurology is limited by a dearth of clinically relevant models. However, here Dr Evangelos Kiskinis, Assistant Professor at Northwestern University Feinberg School of Medicine, discusses how new technologies such as bioelectronic assays enable real-time, long-term analysis of neurological diseases in a dish, offering a pathway towards identifying…
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Cell survival mechanisms identified through RNA regulation in central nervous system
A new study from Niigata University has found a binding protein that is vital for proper development of the central nervous system.
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Analysing proteomics data to translate in vivo studies as early as possible
Dr Antal Szalay, CEO and Founder of Ultimate Medicine, explores how the analysis of omics data, especially metabolomics and proteomics, can provide researchers with vital insight that can inform the development of drugs for conditions associated with age.
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Scientists discover novel B cell that tempers autoimmunity
Infusions of purified IL-27 regulatory B cells (I27-Bregs) reduced symptoms in mouse models of multiple sclerosis and autoimmune uveitis.
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New models for intranasal drug delivery
In this article, Dr Jon Volmer and Dr Jon Lenn discuss a new approach to formulation models to test drug delivery based on reconstituted nasal epithelium.
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Polymerised oestrogen provides neuroprotection in pre-clinical study
The polymerised form of oestrogen has shown success in mice at preventing further damage to the spinal cord after injury.
