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Central Nervous System (CNS)

news

BDNF–VEGF interplay key to rapid antidepressant actions

31 January 2019 | By Dr Zara Kassam (Drug Target Review)

A study reveals a complex interplay of two different growth factors in the rapid and long-lasting antidepressant effects of ketamine...

news

Neurofilament light chains detect Alzheimer’s damage before symptoms

22 January 2019 | By Drug Target Review

A simple blood test reliably detects signs of brain damage in people on the path to developing Alzheimer's disease...

news

Molecules associated with NMDAR may be involved in schizophrenia

18 January 2019 | By Dr Zara Kassam (Drug Target Review)

Genetic variants which prevent a neurotransmitter receptor from working properly have been implicated in the development of schizophrenia...

whitepaper

Application note: GABA_A Receptors

11 December 2018 | By SB Drug Discovery

SB Drug Discovery shows the validation of fluorescence and automated electrophysiology assays designed to assess agonists, antagonists and allosteric modulators of these receptors, culminating in a high-throughput electrophysiology assay suited to assessing multiple GABAA receptor subtypes on a single assay plate.

news

Compounds in coffee may fight Parkinson’s

11 December 2018 | By Drug Target Review

Caffeine plus another compound in coffee beans' waxy coating may protect against brain degeneration...

article

Pharmacological targeting of mitochondrial dysfunction in Parkinson’s disease: approaches and perspectives

19 September 2018 | By Iryna Karaban, Iryna Mankovska, Kateryna Rozova, Larysa Bratus, Olga Gonchar

Mitochondrial dysfunction has been widely implicated in the neuronal degeneration in Parkinson’s disease (PD). Mitochondria-targeted protective compounds that prevent or minimise a wide range of mitochondrial defects constitute potential therapeutic strategies in the prevention and treatment of neuronal degeneration in PD.

news

UBR5 protein may reduce neurodegeneration in Huntington’s disease

27 July 2018 | By Dr Zara Kassam (Drug Target Review)

Scientists have made an important step towards understanding the mechanisms that cause the neurodegenerative disorder Huntington's disease...

news

P2X4 receptor key for delaying the progression of Multiple Sclerosis

23 July 2018 | By Dr Zara Kassam (Drug Target Review)

Researchers have identified a receptor in the microglial cells that increases their anti-inflammatory potential in order to reduce the damage in MS...

news

Aggressive Th17 cells aggravate Parkinson’s disease

21 July 2018 | By Dr Zara Kassam (Drug Target Review)

Researchers identify Parkinson's disease as a possible autoimmune disease...

news

Brain changes responsible for the appetite effects of cannabis identified

17 July 2018 | By Dr Zara Kassam (Drug Target Review)

New research on how cannabis use alters eating behaviour could lead to treatments for appetite loss in chronic illness...

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Central Nervous System (CNS)