news
Editing CHO cells with CRISPR-Cas9 improves cell growth and reduces by-products
Researchers have found bioengineering CHO cells using CRISPR-Cas9 can decrease the secretion of metabolic by-products that hinder growth.
List view / Grid view
CRISPR
news
CRISPR editing can result in whole chromosome elimination, say scientists
In a new study, scientists identify some of the pitfalls when using CRISPR Cas9 to correct mutations in human embryos, such as the destruction of whole chromosomes.
news
Nobel Prize in Chemistry awarded to scientists who discovered CRISPR-Cas9
Emmanuelle Charpentier and Jennifer Doudna have been given the 2020 Nobel Prize in Chemistry for their discovery and development of CRISPR-Cas9 genome editing.
news
CRISPR used to eliminate cancers caused by fusion genes
Using CRISPR to cut out fusion genes, scientists were able to specifically induce cancer cell death in murine models of sarcoma and leukaemia.
news
Using CRISPR to develop a cutaneous leishmaniasis vaccine
Researchers used CRISPR gene-editing to develop a vaccine able to protect against the spread of the Leishmania major parasite which causes cutaneous leishmaniasis.
news
New CRISPR system edits body’s response to prevent immunity against AAVs
A novel CRISPR system that suppresses genes related to adeno-associated virus (AAV) antibody production has been developed to prevent immunity against the gene therapy.
news
Novel CRISPR C-to-G DNA base editor developed by researchers
A new CRISPR technology has been created to understand mutations based on cytosine to guanine base changes and minimise unintended "off-target" mutations.
news
Novel CRISPR enzyme could expand the range of targets for gene therapy
The novel CRISPR-CasΦ enzyme, isolated from bacteriophages, can target a wider range of genetic sequences, say the researchers.
news
Cancer mutation could be used to target CRISPR therapy
Researchers reveal protospacer adjacent motif mutations (PAM sites) on the NRF2 gene of cancers could be used to guide CRISPR gene editing.
news
SARS-CoV-2 mouse model recapitulates human infection
Researchers develop a knock-in mouse expressing human angiotensin-converting enzyme 2 (hACE2) to model SARS-CoV-2 infection for research and therapeutic or vaccine testing.
article
Expert view: CRISPR screening: a powerful approach to drug discovery and development
CRISPR screening utilises the power and precision of CRISPR-Cas9 gene editing to reveal and validate novel drug targets or to study the underlying causes of disease.
news
Gangliosides enable hepatitis A to infect hepatocytes
Researchers use CRISPR-Cas9 gene-editing to establish gangliosides are invoved in hepatitis A entering liver cells, revealing a potential drug target.
news
Induced pluripotent stem cells and CRISPR reversed diabetes in mice
Induced pluripotent stem cells made to produce insulin and CRISPR, used to correct a genetic defect, cured Wolfram syndrome in mice.
news
Using CRISPR-Cas9 to identify new gene drug targets
Researchers have used CRISPR-Cas9 to screen the genome for possible targets that could be used in potential treatments for muscular dystrophy.
news
CRISPR discovery could be used to combat multi-drug resistant bacteria
A study has shown that plasmids use type IV CRISPR-Cas against competing plasmids, leading the researchers to suggest the method as a novel way to tackle multi-drug resistant bacteria.