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Two therapeutic targets identified for lung cancer
Salk scientists discover a pair of enzymes that drive non-small-cell lung cancer by promoting inflammation which could inform the development of new therapies.
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CRISPR
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No-cut CRISPR could be used to treat muscular dystrophy
Researchers have successfully used a no-cut CRISPR gene editing technique as a therapy for muscular dystrophy in mice models.
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Screening identifies gene which protects cells from Zika virus
Researchers used screening to discover genes that protect the body against the Zika virus, which could inform potential therapies against the virus.
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Novel nanoparticles improve CRISPR gene editing
A study has used new synthetic lipids to deliver CRISPR gene editing tools into cells with up to 90 percent efficiency.
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RNA editing capabilities expanded with new CRISPR platform
A research team have developed a new CRISPR platform called RESCUE (RNA Editing for Specific C to U Exchange).
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CRISPR-Cas9 gene editing imaged for first time
Researchers have generated images of CRISPR-Cas9 gene editing for the first time, enabling improvement of the technique.
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Potential cure for HIV revealed through combined therapies
A new study has used combined therapies to eliminate HIV from mice models, providing potential future cures.
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Source of nucleic-acid asymmetry could improve gene therapies
Researchers have analysed the physical origin and biological consequences of DNA-RNA hybrids which could inform gene therapies.
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Dispute over patent rights to CRISPR-Cas9 renewed by patent office
The patent office has declared an interference between 10 University of California (UC) patent applications.
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Experimental treatment for sickle cell disease success
Researchers announce positive pre-clinical results for two sickle cell disease treatment strategies.
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New technology provides process for precise gene editing
Researchers have presented their new technology for accurately inserting genes into the genome without cutting DNA.
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CRISPR/Cas9-engineered cancer models: the next step forward for targeted cancer therapy
The advent of CRISPR/Cas9 gene editing, together with the plummeting cost of whole-genome sequencing, has cleared a path for the development of customised cancer cell models. Here, we discuss recent developments in the field and challenges associated with targeted-therapy resistance.
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Screening In-Depth Focus 2019
This in-depth focus discusses screening and the uses of phenotypic profiling in drug discovery. Also examined is the role that CRISPR/Cas9 gene editing and native mass spectrometry play.
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‘CRISPR babies’ may have shorter life expectancy
A study of almost half a million people links a mutation that protects against HIV infection to an earlier death.
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Drug Target Review – Issue 2 2019
In this issue: novel approaches to produce radiolabelled antibodies, the use of CRISPR/Cas9 to accelerate the development of targeted therapies and utilisation of stem cells to study the effects of cannabis on neuronal development.