news
Cancer-killing combination therapies unveiled with new drug-screening tool
Method IDs which target therapies, inadequately on their own, can be paired up to kill non-responsive cancers...
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CRISPR
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Realising the promise of laboratory automation in biomedical research
Automation offers a choice of powerful ways to design and execute high-quality laboratory research. The use of lab automation is now pervasive in biomedical labs, offering versatile platforms on which to perform an ever‑expanding array of tasks free of human errors, and a unique means to address the problems associated…
news
New cancer drug targets accelerate path to precision medicine
Researchers used CRISPR technology to disrupt every gene in over 300 cancer models from 30 cancer types and discover thousands of key genes essential for cancer's survival...
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New DNA ‘shredder’ technique goes beyond CRISPR’s scissors
A new CRISPR-based tool that acts more like a shredder is able to wipe out long stretches of DNA in human cells with programmable targeting...
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CRISPR/Cas9 shown to limit impact of certain parasitic diseases
Researchers successfully used CRISPR/Cas9 to limit the impact of schistosomiasis and liver fluke infection...
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CRISPR repurposed to develop better antibiotics
Mobile-CRISPRi could be used to guide gene expression, in turn control levels of proteins produced, enabling scientists to identify key antibiotic targets...
whitepaper
Whitepaper: Application of CRISPR/Cas to the generation of genetically engineered mice
Learn how the continued development of CRISPR gene editing technologies opens fresh possibilities for in vivo model design.
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Omics-informed drug target discovery in combating emerging infectious diseases
The catastrophic consequences of ever-increasing rates of death from infectious diseases demands new experimental strategies for drug target selection and drug design. Over the last decade, the pharmaceutical industry has been wounded by several issues including failure of drug-development programmes, burgeoning cost of drug development, increasing regulatory control, lack of…
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CRISPR used to prevent cancers tied to EBV and KSHV
Researchers have discovered a possible path forward in preventing the development of cancers tied to two viruses, including the virus that causes infectious mononucleosis...
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New Cas9 enzyme widens scope for CRISPR genome editing
A team of researchers has discovered a Cas9 enzyme that can target almost half of the locations on the genome, significantly widening its potential application.
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GFAP gene mutation creates tangles in brain cells – cause of neurological disease
A recent study in the U.S. has identified how a mutation in the GFAP gene, which encodes for the GFAP protein, causes the tangles in brain cells associated with Alexander disease and may also impact other neurological diseases.
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Critical cancer immunity genes identified using genetic barcoding
Genetic barcoding using Pro-codes and CRISPR could be used to identify critical cancer immunity genes to aid future therapeutics...
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Prenatal gene editing used in treating congenital disease before birth
Researchers show the first example of a base-editing tool to treat a disease in utero in animal models...
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Np63a should be targeted in squamous cell carcinomas
A team of researchers have identified that to target p63, both TGFB2 and RHOA tumour suppressor genes should be activated...
news
CRISPR used to deliver BChE into cells to protect from lethal cocaine doses
Researchers have described a novel approach that was able to stifle the desire for cocaine and to protect against an overdose...