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A recent study in the U.S. has identified how a mutation in the GFAP gene, which encodes for the GFAP protein, causes the tangles in brain cells associated with Alexander disease and may also impact other neurological diseases.
Genetic barcoding using Pro-codes and CRISPR could be used to identify critical cancer immunity genes to aid future therapeutics...
Researchers show the first example of a base-editing tool to treat a disease in utero in animal models...
A team of researchers have identified that to target p63, both TGFB2 and RHOA tumour suppressor genes should be activated...
Researchers have described a novel approach that was able to stifle the desire for cocaine and to protect against an overdose...
Growing evidence reveals that using single immunotherapies to treat oncological disorders may lead to cancer-killing T-cell overdrive,initiating life-threatening autoimmune reactions including cytokinestorm; also known as hypercytokinemia or Cytokine Release Syndrome(CRS). Recently, checkpoint blockade using anti-programmed cell death1 (anti-PD-1) inhibitors became a prevalent approach for stimulatinganti-tumour immune system.
Complex biology is a discipline acknowledging that performing biological experiments in vitro should take account of the complexity of the biological context.1 While this may be a noble aim, it has proven difficult to incorporate these elements into the drug discovery process, especially at the high-throughput screening (HTS) stage.2
Researchers have developed a new CHAOS method to combat antibiotic resistance, using CRISPR DNA modification techniques...
Researchers have adapted CRISPR to cause the cell's internal machinery to skip over a small portion of a gene when transcribing it into a template for protein building...
Genome editing using the CRISPR-Cas9 system has tremendous promise for therapeutic correction of genetic errors in human cells...
Scientists have identified an easy upgrade for the technology that would lead to more accurate gene editing...
The team found that astrocytes inhibit growth of precursor cells that become myelin, and speed up the neural network in the brain...
A protein identified in the signalling pathway for haemoglobin production has been identified as a possible target to treat sickle cell disease (SCD)...
The discovery is a major step toward understanding the mechanisms of myelin production and the potential for treating certain central nervous system diseases...
