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Np63a should be targeted in squamous cell carcinomas
A team of researchers have identified that to target p63, both TGFB2 and RHOA tumour suppressor genes should be activated...
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CRISPR
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CRISPR used to deliver BChE into cells to protect from lethal cocaine doses
Researchers have described a novel approach that was able to stifle the desire for cocaine and to protect against an overdose...
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Expert view: Assays to measure the potency of therapeutic antibodies used in combination with other drugs for Immuno‑Oncology treatments
Growing evidence reveals that using single immunotherapies to treat oncological disorders may lead to cancer-killing T-cell overdrive,initiating life-threatening autoimmune reactions including cytokinestorm; also known as hypercytokinemia or Cytokine Release Syndrome(CRS). Recently, checkpoint blockade using anti-programmed cell death1 (anti-PD-1) inhibitors became a prevalent approach for stimulatinganti-tumour immune system.
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Complex biology for the precision medicine era: re-thinking the drug discovery process
Complex biology is a discipline acknowledging that performing biological experiments in vitro should take account of the complexity of the biological context.1 While this may be a noble aim, it has proven difficult to incorporate these elements into the drug discovery process, especially at the high-throughput screening (HTS) stage.2
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CHAOS approach to antibiotic resistance
Researchers have developed a new CHAOS method to combat antibiotic resistance, using CRISPR DNA modification techniques...
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CRISPR technique skips over portions of genes that can cause disease
Researchers have adapted CRISPR to cause the cell's internal machinery to skip over a small portion of a gene when transcribing it into a template for protein building...
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CRISPR-Cas9 used to correct sickle cell–causing mutation
Genome editing using the CRISPR-Cas9 system has tremendous promise for therapeutic correction of genetic errors in human cells...
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Cas12a enzyme could make CRISPR gene-editing more effective
Scientists have identified an easy upgrade for the technology that would lead to more accurate gene editing...
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New stem cell model to test treatments for neurodegenerative disorders
The team found that astrocytes inhibit growth of precursor cells that become myelin, and speed up the neural network in the brain...
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HRI depletion may be effective in treating sickle cell disease
A protein identified in the signalling pathway for haemoglobin production has been identified as a possible target to treat sickle cell disease (SCD)...
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Scientists uncover the role of PRMT5 in the production of myelin-forming cells
The discovery is a major step toward understanding the mechanisms of myelin production and the potential for treating certain central nervous system diseases...
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CRISPRa used to reprogramme skin cells into pluripotent stem cells
Researchers have now for the first time succeeded in converting skin cells into pluripotent stem cells by activating the cell's own genes...
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CRISPR technology can correct Alpha-1 antitrypsin deficiency
Groundbreaking research demonstrates proof-of-concept for using CRISPR-Cas9 genome editing technology to correct the gene mutation responsible for AAT deficiency...
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CRISPR-Gold used to reduce repetitive behaviours in FXS
Gold nanoparticles carried Cas9 enzyme into brain, editing receptor and lessening burying behaviour...