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CRISPR

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CRISPRa used to reprogramme skin cells into pluripotent stem cells

6 July 2018 | By Dr Zara Kassam (Drug Target Review)

Researchers have now for the first time succeeded in converting skin cells into pluripotent stem cells by activating the cell's own genes...

news

CRISPR technology can correct Alpha-1 antitrypsin deficiency

4 July 2018 | By Dr Zara Kassam (Drug Target Review)

Groundbreaking research demonstrates proof-of-concept for using CRISPR-Cas9 genome editing technology to correct the gene mutation responsible for AAT deficiency...

news

CRISPR-Gold used to reduce repetitive behaviours in FXS

26 June 2018 | By Drug Target Review

Gold nanoparticles carried Cas9 enzyme into brain, editing receptor and lessening burying behaviour...

news

CRISPR technology may improve accuracy of predicting heart disease risk

19 June 2018 | By Dr Zara Kassam (Drug Target Review)

Scientists may now be able to predict whether carrying a specific genetic variant increases a person's risk for disease using gene editing and stem cell technologies...

news

CRISPR-Cas9 tool could increase cancer risk

12 June 2018 | By Dr Zara Kassam (Drug Target Review)

Therapeutic use of gene editing with the so-called CRISPR-Cas9 technique may inadvertently increase the risk of cancer...

article

Expert view: It’s an exciting time for the use of stem cells in research and the treatment of human disease

8 June 2018 | By Dan Appledorn (Director of US Biology - Essen Bioscience)

The Nobel Prize-winning observations and discoveries of John B. Gurdon and Shinya Yamanaka have ignited an explosion of excitement around the potential use of stem cells in research and treatment of human disease.

news

APOE4 gene variant linked to Alzheimer’s

4 June 2018 | By Dr Zara Kassam (Drug Target Review)

A study reveals why people with the APOE4 gene have a higher risk of the disease...

news

CRISPR approach could limit toxicity of CAR-T therapy in AML

4 June 2018 | By Dr Zara Kassam (Drug Target Review)

New study uses CRISPR/Cas9 to make CD33 CAR T cells cancer-specific...

news

CRISPR used to destroy the regulatory genes of HIV

21 May 2018 | By Dr Zara Kassam (Drug Target Review)

By destroying the regulatory genes of the AIDS virus HIV-1 using the genome editing system CRISPR/Cas9, researchers have succeeded in blocking the production of HIV-1 by infected cells...

news

CRISPR used to restore retinal function

14 May 2018 | By Dr Zara Kassam (Drug Target Review)

Researchers have developed a new technique to restore retinal function in mice afflicted by a degenerative retinal disease, retinitis pigmentosa...

whitepaper

Whitepaper: Smart cell monitoring

3 May 2018 | By Del Trezise, Essen BioScience

This whitepaper outlines how advances in real-time live-cell monitoring and analysis methods are addressing these changing needs.

news

CRISPR used to improve red blood cell transfusion compatibility

1 May 2018 | By Dr Zara Kassam (Drug Target Review)

Scientists have created individual cell lines in which specific blood group genes were altered to prevent the expression of blood group proteins...

webinar

in vitro phenotypic assays for Parkinson’s disease

26 April 2018 | By Charles River Laboratories

This webinar highlights cell based assays for Parkinson’s disease that include endpoints such as a-synuclein aggregation and mitophagy readouts.

news

CRISPR used to edit DNA outside of the cell

23 April 2018 | By Dr Zara Kassam (Drug Target Review)

Scientists have developed a breakthrough CRISPR gene-editing tool, that could allow researchers to quickly and precisely engineer multiple changes to the genetic code...

whitepaper

Application note: CRISPR/Cas9 genome-edited cells express nanoBRET-donor that monitors protein interaction and trafficking

12 April 2018 | By BMG Labtech GmbH, Carl White (Molecular Endocrinology and Pharmacology), Ethan See (The University of Western Australia), Kevin Pfleger (Dimerix Limited)

In this application note, BMG Labtech discuss how the Bioluminescence resonance energy transfer (BRET) is a versatile tool to study interactions and trafficking in proteins.

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CRISPR