news New stem cell model to test treatments for neurodegenerative disorders 2 August 2018 | By Drug Target Review The team found that astrocytes inhibit growth of precursor cells that become myelin, and speed up the neural network in the brain...
news HRI depletion may be effective in treating sickle cell disease 20 July 2018 | By Drug Target Review A protein identified in the signalling pathway for haemoglobin production has been identified as a possible target to treat sickle cell disease (SCD)...
news Scientists uncover the role of PRMT5 in the production of myelin-forming cells 19 July 2018 | By Dr Zara Kassam (Drug Target Review) The discovery is a major step toward understanding the mechanisms of myelin production and the potential for treating certain central nervous system diseases...
news CRISPRa used to reprogramme skin cells into pluripotent stem cells 6 July 2018 | By Dr Zara Kassam (Drug Target Review) Researchers have now for the first time succeeded in converting skin cells into pluripotent stem cells by activating the cell's own genes...
news CRISPR technology can correct Alpha-1 antitrypsin deficiency 4 July 2018 | By Dr Zara Kassam (Drug Target Review) Groundbreaking research demonstrates proof-of-concept for using CRISPR-Cas9 genome editing technology to correct the gene mutation responsible for AAT deficiency...
news CRISPR-Gold used to reduce repetitive behaviours in FXS 26 June 2018 | By Drug Target Review Gold nanoparticles carried Cas9 enzyme into brain, editing receptor and lessening burying behaviour...
news CRISPR technology may improve accuracy of predicting heart disease risk 19 June 2018 | By Dr Zara Kassam (Drug Target Review) Scientists may now be able to predict whether carrying a specific genetic variant increases a person's risk for disease using gene editing and stem cell technologies...
news CRISPR-Cas9 tool could increase cancer risk 12 June 2018 | By Dr Zara Kassam (Drug Target Review) Therapeutic use of gene editing with the so-called CRISPR-Cas9 technique may inadvertently increase the risk of cancer...
article Expert view: It’s an exciting time for the use of stem cells in research and the treatment of human disease 8 June 2018 | By Dan Appledorn (Director of US Biology - Essen Bioscience) The Nobel Prize-winning observations and discoveries of John B. Gurdon and Shinya Yamanaka have ignited an explosion of excitement around the potential use of stem cells in research and treatment of human disease.
news APOE4 gene variant linked to Alzheimer’s 4 June 2018 | By Dr Zara Kassam (Drug Target Review) A study reveals why people with the APOE4 gene have a higher risk of the disease...
news CRISPR approach could limit toxicity of CAR-T therapy in AML 4 June 2018 | By Dr Zara Kassam (Drug Target Review) New study uses CRISPR/Cas9 to make CD33 CAR T cells cancer-specific...
news CRISPR used to destroy the regulatory genes of HIV 21 May 2018 | By Dr Zara Kassam (Drug Target Review) By destroying the regulatory genes of the AIDS virus HIV-1 using the genome editing system CRISPR/Cas9, researchers have succeeded in blocking the production of HIV-1 by infected cells...
news CRISPR used to restore retinal function 14 May 2018 | By Dr Zara Kassam (Drug Target Review) Researchers have developed a new technique to restore retinal function in mice afflicted by a degenerative retinal disease, retinitis pigmentosa...
whitepaper Whitepaper: Smart cell monitoring 3 May 2018 | By Del Trezise, Essen BioScience This whitepaper outlines how advances in real-time live-cell monitoring and analysis methods are addressing these changing needs.
news CRISPR used to improve red blood cell transfusion compatibility 1 May 2018 | By Dr Zara Kassam (Drug Target Review) Scientists have created individual cell lines in which specific blood group genes were altered to prevent the expression of blood group proteins...
