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CRISPR

news

CRISPR-Cas9 tool could increase cancer risk

12 June 2018 | By Dr Zara Kassam (Drug Target Review)

Therapeutic use of gene editing with the so-called CRISPR-Cas9 technique may inadvertently increase the risk of cancer...

article

Expert view: It’s an exciting time for the use of stem cells in research and the treatment of human disease

8 June 2018 | By Dan Appledorn (Director of US Biology - Essen Bioscience)

The Nobel Prize-winning observations and discoveries of John B. Gurdon and Shinya Yamanaka have ignited an explosion of excitement around the potential use of stem cells in research and treatment of human disease.

news

APOE4 gene variant linked to Alzheimer’s

4 June 2018 | By Dr Zara Kassam (Drug Target Review)

A study reveals why people with the APOE4 gene have a higher risk of the disease...

news

CRISPR approach could limit toxicity of CAR-T therapy in AML

4 June 2018 | By Dr Zara Kassam (Drug Target Review)

New study uses CRISPR/Cas9 to make CD33 CAR T cells cancer-specific...

news

CRISPR used to destroy the regulatory genes of HIV

21 May 2018 | By Dr Zara Kassam (Drug Target Review)

By destroying the regulatory genes of the AIDS virus HIV-1 using the genome editing system CRISPR/Cas9, researchers have succeeded in blocking the production of HIV-1 by infected cells...

news

CRISPR used to restore retinal function

14 May 2018 | By Dr Zara Kassam (Drug Target Review)

Researchers have developed a new technique to restore retinal function in mice afflicted by a degenerative retinal disease, retinitis pigmentosa...

whitepaper

Whitepaper: Smart cell monitoring

3 May 2018 | By Del Trezise, Essen BioScience

This whitepaper outlines how advances in real-time live-cell monitoring and analysis methods are addressing these changing needs.

news

CRISPR used to improve red blood cell transfusion compatibility

1 May 2018 | By Dr Zara Kassam (Drug Target Review)

Scientists have created individual cell lines in which specific blood group genes were altered to prevent the expression of blood group proteins...

webinar

in vitro phenotypic assays for Parkinson’s disease

26 April 2018 | By Charles River Laboratories

This webinar highlights cell based assays for Parkinson’s disease that include endpoints such as a-synuclein aggregation and mitophagy readouts.

news

CRISPR used to edit DNA outside of the cell

23 April 2018 | By Dr Zara Kassam (Drug Target Review)

Scientists have developed a breakthrough CRISPR gene-editing tool, that could allow researchers to quickly and precisely engineer multiple changes to the genetic code...

whitepaper

Application note: CRISPR/Cas9 genome-edited cells express nanoBRET-donor that monitors protein interaction and trafficking

12 April 2018 | By BMG Labtech GmbH, Carl White (Molecular Endocrinology and Pharmacology), Ethan See (The University of Western Australia), Kevin Pfleger (Dimerix Limited)

In this application note, BMG Labtech discuss how the Bioluminescence resonance energy transfer (BRET) is a versatile tool to study interactions and trafficking in proteins.

news

Animal model of Huntington’s offers advantages for testing treatments

2 April 2018 | By Dr Zara Kassam (Drug Target Review)

Using genetic engineering technology, a team of scientists have established an animal model of Huntington's disease...

Alessandro Spedito Global Strategy Manager, CRO and Preclinical presso Merck Group

article

Expert view: Screening tools for better lead characterisation

19 March 2018 | By Alessandro Spedito (Global Strategy Manager, CRO and Preclinical presso Merck Group)

Predictiveness is one of the key factors for success in the drug discovery workflow. Many compounds fail at late stages due to lack of predictive data or the discovery of unwanted side effects.

news

CRISPR helps find new genetic suspects behind ALS/FTD

13 March 2018 | By Dr Zara Kassam (Drug Target Review)

Study provides a roadmap for using CRISPR to investigate neurological disorders...

news

CRISPR/Cas9 technique suppresses malaria infection in mosquitos

9 March 2018 | By Dr Zara Kassam (Drug Target Review)

Genome editing could enable new strategies to prevent malaria transmission to humans...

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CRISPR