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CRISPR

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CRISPR technique skips over portions of genes that can cause disease

17 August 2018 | By Dr Zara Kassam (Drug Target Review)

Researchers have adapted CRISPR to cause the cell's internal machinery to skip over a small portion of a gene when transcribing it into a template for protein building...

Pushpanathan Muthuirulan Harvard University, Cambridge

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Pushpanathan Muthuirulan

13 August 2018 | By

Research Associate, Harvard University

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CRISPR-Cas9 used to correct sickle cell–causing mutation

7 August 2018 | By Dr Zara Kassam (Drug Target Review)

Genome editing using the CRISPR-Cas9 system has tremendous promise for therapeutic correction of genetic errors in human cells...

news

Cas12a enzyme could make CRISPR gene-editing more effective

2 August 2018 | By Dr Zara Kassam (Drug Target Review)

Scientists have identified an easy upgrade for the technology that would lead to more accurate gene editing...

news

New stem cell model to test treatments for neurodegenerative disorders

2 August 2018 | By Drug Target Review

The team found that astrocytes inhibit growth of precursor cells that become myelin, and speed up the neural network in the brain...

news

HRI depletion may be effective in treating sickle cell disease

20 July 2018 | By Drug Target Review

A protein identified in the signalling pathway for haemoglobin production has been identified as a possible target to treat sickle cell disease (SCD)...

news

Scientists uncover the role of PRMT5 in the production of myelin-forming cells

19 July 2018 | By Dr Zara Kassam (Drug Target Review)

The discovery is a major step toward understanding the mechanisms of myelin production and the potential for treating certain central nervous system diseases...

news

CRISPRa used to reprogramme skin cells into pluripotent stem cells

6 July 2018 | By Dr Zara Kassam (Drug Target Review)

Researchers have now for the first time succeeded in converting skin cells into pluripotent stem cells by activating the cell's own genes...

news

CRISPR technology can correct Alpha-1 antitrypsin deficiency

4 July 2018 | By Dr Zara Kassam (Drug Target Review)

Groundbreaking research demonstrates proof-of-concept for using CRISPR-Cas9 genome editing technology to correct the gene mutation responsible for AAT deficiency...

news

CRISPR-Gold used to reduce repetitive behaviours in FXS

26 June 2018 | By Drug Target Review

Gold nanoparticles carried Cas9 enzyme into brain, editing receptor and lessening burying behaviour...

news

CRISPR technology may improve accuracy of predicting heart disease risk

19 June 2018 | By Dr Zara Kassam (Drug Target Review)

Scientists may now be able to predict whether carrying a specific genetic variant increases a person's risk for disease using gene editing and stem cell technologies...

news

CRISPR-Cas9 tool could increase cancer risk

12 June 2018 | By Dr Zara Kassam (Drug Target Review)

Therapeutic use of gene editing with the so-called CRISPR-Cas9 technique may inadvertently increase the risk of cancer...

article

Expert view: It’s an exciting time for the use of stem cells in research and the treatment of human disease

8 June 2018 | By Dan Appledorn (Director of US Biology - Essen Bioscience)

The Nobel Prize-winning observations and discoveries of John B. Gurdon and Shinya Yamanaka have ignited an explosion of excitement around the potential use of stem cells in research and treatment of human disease.

news

APOE4 gene variant linked to Alzheimer’s

4 June 2018 | By Dr Zara Kassam (Drug Target Review)

A study reveals why people with the APOE4 gene have a higher risk of the disease...

news

CRISPR approach could limit toxicity of CAR-T therapy in AML

4 June 2018 | By Dr Zara Kassam (Drug Target Review)

New study uses CRISPR/Cas9 to make CD33 CAR T cells cancer-specific...

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CRISPR