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CRISPR

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CRISPR used to identify drug target for bowel cancer

17 October 2017 | By Dr Zara Kassam (Drug Target Review)

CRISPR used to identify a new drug target for bowel cancer that is specific to tumour cells and therefore less toxic than conventional therapies...

news

Modified CRISPR technique used to combat Parkinson’s disease

13 October 2017 | By Dr Zara Kassam (Drug Target Review)

Biological engineers identify genes that protect against protein linked to Parkinson's disease...

news

Microcapsules to enhance the efficiency of genome-editing

6 October 2017 | By Dr Zara Kassam (Drug Target Review)

Researchers have found that polymer and hybrid silica-coated microcapsules are efficient in genome-editing...

news

CRISPR-engineered cancer model to test therapeutics

5 October 2017 | By Dr Zara Kassam (Drug Target Review)

A new technique for modelling leukaemia may aid drug discovery...

news

CRISPR-Cas9 used to systematically inactivate genes in colorectal cancer

28 September 2017 | By Dr Zara Kassam (Drug Target Review)

Researchers have used CRISPR-Cas9 to inactivate genes in human colorectal cancer cell lines -- one with normal KRAS gene and one with a mutant KRAS...

news

Genome editing reveals a role for OCT4 in human embryogenesis

21 September 2017 | By Dr Zara Kassam (Drug Target Review)

Researchers have used genome editing technology to reveal the role of a key gene in human embryos in the first few days of development...

news

GREB1L mutations associated with renal agenesis

19 September 2017 | By Dr Zara Kassam (Drug Target Review)

A team of researchers has identified the mutated gene GREB1L is linked to renal agenesis...

news

CRISPR-Cas9 technology used to study hereditary forms of cancer

14 September 2017 | By Dr Zara Kassam (Drug Target Review)

Researchers have developed a method, based on CRISPR-Cas9 technology in organoids, to study the genetic cause of hereditary forms of cancer...

article

Expert view: Effective coupling of assays and cell models

11 September 2017 | By Steven G Jarvis (Head of Pharma & Biotech Segment Strategy - MilliporeSigma)

Assay robustness tends to be the favoured descriptor when a particular assay can cope with minute changes in the sample, equipment, or operator. The more robust an assay, the more predictive data it ultimately yields. The industry’s greatest challenge for assay development has always been using those robust assays to…

news

CRISPR gives new insight into autoimmune disorders

1 September 2017 | By Dr Zara Kassam (Drug Target Review)

Researchers have used a modified version of the gene-editing technique CRISPR in search for gene activators...

news

Scientists characterise regulatory DNA sequences responsible for human diseases

25 August 2017 | By Dr Zara Kassam (Drug Target Review)

Scientists have developed an innovative system to identify and characterise the molecular components that control the activities of regulatory DNA sequences...

news

CRISPR identifies essential genes for cancer immunotherapy

8 August 2017 | By Dr Zara Kassam (Drug Target Review)

Researchers have used CRISPR to stop the expression of individual genes in cancer cells, by knocking out every known protein-encoding gene in the human genome...

article

CRISPR-Cas9 repairs genetic mutation in human embryos

3 August 2017 | By James Adjaye (Institute for Stem Cell Research and Regenerative Medicine), Justin Bryans, Steve Bremer (Drug Target Review)

"Well thought through and brilliantly executed" study shows different DNA-repair mechanism in embryos compared to iPSCs

David F Fischer, PhD, Executive Director Biology at Charles River

article

David F Fischer on target screening

10 July 2017 | By Drug Target Review

Drug Target Review editor Steve Bremer asks David F Fischer for his views on target discovery and validation in drug discovery. David F Fischer, PhD, is Executive Director Biology at Charles River...

article

New drug targets identified to defend against chlamydia infections using CRISPR and stem cells

7 July 2017 | By Amy Yeung (Wellcome Trust Sanger Institute)

Human induced pluripotent stem cell derived macrophages (iPSDMs) provide a cell-based model system to study chlamydia infection in the laboratory. Amy Yeung from Wellcome Trust Sanger Institute explains how she used this model in combination with CRISPR-Cas 9 technology to explore the potential of the two genes, IRF5 and IL10RA,…

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CRISPR