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Scientists develop new CRISPR-based tool to control epigenome
Researchers have used CRISPR to create a new technology that can switch off almost any gene in cells, called CRISPRoff.
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CRISPR
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Application note: Effectiveness of CRISPR‑Cas9 using pools of synthetic crRNAs in high-content analysis screening experiments
In this application note, discover how pools of synthetic crRNAs can produce a phenotype as strong as, or stronger, than any one of the component crRNAs in arrayed CRISPR screening experiments.
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Prime editing demonstrates success at precise gene editing in mice
Researchers have shown that prime editing is able to effectively edit genes in mice but without the off-target effects of CRISPR.
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Nano-micelles used in CRISPR genome editing of mouse brains
Researchers have reported that nano-micelles can be used to efficiently deliver CRISPR-Cas9 to edit genes in the brains of mice.
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CRISPR-dead Cas9 could offer non-addictive treatment for pain, study shows
A new CRISPR gene therapy for chronic pain has been shown in mice to temporarily repress a gene involved in sensing pain.
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Nanobodies could help CRISPR turn genes on and off
Researchers have used nanobodies to act as an assistant to CRISPR, bringing in effectors to turn specific genes on and off.
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New CRISPR tool could enable gene editing over time, study shows
Researchers have shown that a guide RNA can be used in CRISPR gene editing to ensure sequential Cas9 cuts to DNA.
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CRISPR used to model acute myeloid leukaemia progression
CRISPR-Cas9 and stem cell technologies have been used to create a cellular model of acute myeloid leukaemia, revealing therapeutic targets.
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TALEN is a more efficient gene editing tool for tightly packed DNA, finds study
TALEN was shown to be almost five times more efficient than CRISPR-Cas9 at locating and editing genes in heterochromatin.
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CRISPR: three new developments in the world of gene editing
In this article, we outline three recent studies that have advanced the potential uses of CRISPR in the biomedical field.
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New DNA-editing technique extends lifespan of mice with progeria
Researchers have used a novel DNA-editing method to convert one base pair to another, increasing the lifespan of mice with progeria.
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CRISPR tagging used to grow neuronal cells from stem cells
A new technique using CRISPR has been developed by researchers to identify programmed stem cells that mature into neuronal cells.
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Advancing CHO cell line engineering with CRISPR
Chinese hamster ovary (CHO) cell lines are a firm favourite with biologics companies because of the extensive developmental work undertaken in recent decades. In this article, Junrui Li divulges how CRISPR technology is now being employed to further enhance productivity.
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CRISPR: a molecular scissor set to change the world
In October this year, Emmanuelle Charpentier and Jennifer Doudna, the two scientists who pioneered the revolutionary gene-editing technology CRISPR, were awarded the Nobel Prize in Chemistry. Here, Pushpanathan Muthuirulan discusses the potential for this technology and the importance of using it safely, ethically and responsibly.
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Upstream Bioprocessing In-Depth Focus 2020
In the upstream bioprocessing in-depth focus experts reveal how CRISPR is being leveraged to enhance productivity in cell line development and why industry is focusing on producing animal-component free glycosaminoglycans.