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Cytotoxicity assays

3D Rendering of Antibody Drug Conjugate - ADC

Refining and targeting exatecan with ADC technology

10 March 2025 | By Drug Target Review

DTR speaks with Dr Patrick van Berkel at ADC Therapeutics to discuss how the company is transforming exatecan delivery to achieve better health outcomes.

news

Assay to reveal anti-tumour T-cell cytotoxicity via flow cytometry developed

20 October 2020 | By Victoria Rees (Drug Target Review)

A simple co-culture assay that can assess anti-tumour T-cell cytotoxicity via luminescence and flow cytometry has been created.

article

The importance of characterising chemical starting points of drugs using appropriate in vitro ADME-toxicity assays

21 March 2019 | By Massimiliano Runfola - University of Pisa - Italy, Sheraz Gul - Fraunhofer IME - Germany

Over the past 30 years, one strategy the pharmaceutical industry has adopted in the drug discovery process has been to “fail early, fail often”.1,2 As most molecules in the early stages of drug discovery will have sub-optimal characteristics, significant modification is necessary to improve their properties.

whitepaper

Application note: Fc-Receptor binding in ADCC assays utilising LANCE Ultra Technology – characterisation of hIGs and FcγRIIIa

4 January 2018 | By Daniel Cardillo (PerkinElmer), Hong Cao (PerkinElmer), Stephen Hurt (PerkinElmer)

In this application note, PerkinElmer demonstrates the ease and utility of using LANCE® Ultra, a homogeneous assay format, for determining binding profiles of therapeutic monoclonal antibodies to FcγRs.

Implementing ADCC assays in QC: When donor variability isn’t an option

article

Q&A: Implementing ADCC assays in QC: when donor variability isn’t an option

12 December 2017 | By Drug Target Review

DiscoverX recently introduced the single donor-derived KILR CD16 Effector Cells to ensure assay reproducibility for screening, characterisation, and QC lot release of antibody drugs.

webinar

Implementing ADCC assays in QC: When donor variability isn’t an option

6 October 2017 | By DiscoverX Corporation

In this webinar, we discussed how two qualification studies on KILR CD16 Effector Cells demonstrated accuracy and precision in different assays formats.

whitepaper

Application note: A high-throughput, radioactivity-free assay for cell-mediated cytotoxicity

25 September 2017 | By IntelliCyt Corporation

In this application note, IntelliCyt Corporation demonstrate a fast, efficient, radioactivity-free CMC assay with low sample input requirements, enabling miniaturisation to 384-well plates, using the iQue® Screener...

App Note- Luminescent cell viability and cytotoxicity assays

whitepaper

App Note: Luminescent cell viability and cytotoxicity assays

18 December 2015 | By Molecular Devices

This application note details a highly sensitive and rapid way to measure viable cells in culture and quantify cytotoxic effects of experimental treatment...

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Cytotoxicity assays