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Personalised organoid models for rare spinal cancer
Scientists have successfully created viable organoids from tumour samples from five patients with a rare bone cancer called a chordoma, which has few therapeutic options.
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Disease Research
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Extracellular vesicles: a new target for understanding endocrine disorders
Scientists at the Endocrine Society have found extracellular vesicles may offer new insights into treating endocrine disorders.
video
Video: Anti-Idiotypic antibodies for development of CAR T cell therapies
Interview with Michael Schwenkert, Bio-Rad Laboratories, on best practices for the characterisation and quality control of anti-idiotypic antibodies for bioanalysis.
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Novel technique to rapidly find prostate cancer drugs
A new screening assay could be used to identify new drugs to treat resistant forms of prostate cancer.
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New combinatorial strategies to treat ovarian cancer
Researchers have found how ovarian cancer tumours defy immunotherapy, identifying new molecular targets that might boost immune response.
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Blocking host proteins: an improved COVID-19 treatment approach?
Scientists report news of a promising new compound that effectively blocks the activity of proteins on cells that are necessary for SARS-CoV-2 to cause infection.
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Key takeaways from the AACR Meeting 2022
Drug Target Review's Editor Victoria Rees brings you the highlights from the American Association for Cancer Research Meeting 2022.
webinar
An efficient and effective PIM3 kinase-focused screening cascade for identification of multiple novel and tractable hit series
14 April 2022 | By Eurofins Discovery Services
Watch this free on-demand webinar to understand how to rapidly identify selective, specific, potent and tractable hit series with appropriate ADME characteristics to speed up hit-to-lead.
news
Preventing tumour growth
Researchers have developed a novel substance that disables a protein in the cell skeleton, leading to cell death. In this way, substances of this type can prevent the growth of tumours.
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Researchers plan to image every cell in the human brain at unprecedented speed
Columbia-led team wins research grant to create fundamentally new maps that will chart cell diversity throughout the brains of humans.
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Pfizer to acquire ReViral and its respiratory syncytial virus therapeutic candidates
Pfizer has announced its acquisition of ReViral to advance disease research and development with a complementary strategy to help improve patient outcomes through treatment for respiratory syncytial virus infections and prevent illness through vaccination.
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VBI Vaccines announces progress from coronavirus programme
Pre-clinical research from VBI Vaccines has demonstrated an encouraging ability to boost and broaden the immune response against the coronavirus Beta variant.
news
Innovative therapy that “tricks” and destroys cancer cells
New research has shown iron-like compound holds promise for treating patients with glioblastoma, an aggressive brain cancer.
article
Viewing disease through the lens of memory B cells: improving cancer and infectious disease treatment
Looking at disease through a patient’s memory B cells can reveal vulnerabilities within pathogens. In this article, Dr Purnanand Sarma, President and Chief Executive Officer of Immunome, explores how advancements in memory B-cell antibody-based treatments will improve our understanding of how these cells can aid in fighting cancer and other diseases.
news
Signatures of certain RNA molecules may help improve disease diagnostics
Scientists have found that molecules produced by cells in response to stress may be indicators of various diseases.