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Explaining sex differences in adipose insulin resistance

14 May 2024 | By Drug Target Review

Heightened insulin resistance in obese men may elucidate the higher prevalence of type 2 diabetes among these individuals.

whitepaper

Poster: Assays for PRMT5, MLL4, METTL3/14, & NSP14

7 May 2024 | By BellBrook Labs

AptaFluor SAH: A Homogenous, Universal Assay for Histone, RNA, & DNA Methyltransferases. Case Study for PRMT5, MLL4, METTL3/14, & NSP14

Women scientists nurses and doctors fighting against coronavirus. Feminist steminist illustration. Female Doctors, nurses and scientists together.

article

Women in Stem with Stefanie Flückiger-Mangual

6 May 2024 | By Stefanie Flückiger-Mangual (TOLREMO Therapeutics)

Stefanie Flückiger-Mangual, Chief Executive Officer, is one of TOLREMO’s scientific founders and an expert in drug resistance in cancer therapy. She is a biomedical scientist and biochemist by training (University of Fribourg and ETH Zurich, Switzerland) and holds a PhD in Molecular and Translational Biomedicine from ETH Zurich. She led…

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Quantitative assessment of cerebral small vessel disease risk

3 May 2024 | By Drug Target Review

Researchers discovered that measuring the concentrations of IL-18 in an individual’s blood could estimate future risk of stroke.

news

Elevated TMAO levels predict future risk of CKD

11 April 2024 | By Drug Target Review

Elevated levels of trimethylamine N-oxide levels were a stronger indicator of CKD risk than the well-known risk factors.

article

Bile acids and the microbiome: revolutionising disease approaches

12 March 2024 | By Ellen Capon (Drug Target Review)

Thousands of bile acids have been discovered, providing new insights into how microbes influence distant organ systems.

podcasts

CRISPR/Cas: exploring its impact on gene editing

8 March 2024 | By Drug Target Review, Molecular Devices

Tune in to this episode where we discuss the opportunities CRISPR/Cas technology offers to revolutionise drug discovery.

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Uncovering the changes to β-cells at the onset of type 1 diabetes

27 February 2024 | By Drug Target Review

A new study provides more clarity about the immune events surrounding the onset of T1D, including a new mechanism that could be used for β-cell protection.

news

4PY found to directly trigger vascular inflammation

21 February 2024 | By Drug Target Review

Researchers have discovered a new pathway which seems to be a significant contributor to the development of cardiovascular disease.

news

Uncovering the bidirectional relationship between PD and DM

16 February 2024 | By Drug Target Review

Single-cell RNA analysis provides an immunological explanation for the association between periodontitis and diabetes mellitus.

whitepaper

A Guide to Measuring Drug-Target Residence Times

7 February 2024 | By BellBrook Labs

This guide provides technical background on concepts and techniques for use of Transcreener biochemical assays to measure drug-target residence times.

news

Improving treatments for rheumatoid arthritis patients

7 February 2024 | By Drug Target Review

Researchers found that resolvinT4 restores protective macrophage biological activities in rheumatoid arthritis patients.

news

Advantages of using cfDNA sequencing for early detection of GDM

2 February 2024 | By Drug Target Review

A deep learning model developed using circulating cell-free DNA outperformed traditional screening methods for gestational diabetes mellitus.

article

How 3D human tissue models are transforming drug discovery

2 February 2024 | By Ellen Capon (Drug Target Review), Keith Murphy (Organovo)

In this Q&A, Keith Murphy, CEO of Organovo, discusses how the shift from animal models to 3D human tissues can transform the preclinical space. Among his many insights, he details the limitations of animal models, how Organovo’s 3D human tissue models facilitate a deeper understanding of genetic expression within specific…

news

Advancing the understanding of placenta accreta spectrum disorder

1 February 2024 | By Drug Target Review

A new study has identified targets to refine diagnostic tests, track disease progression, and discover more effective therapies.

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