news
New biological pathway in IBD discovered
Researchers have identified a new biological pathway driving IBD and similar conditions that could be targeted with MEK inhibitors.
List view / Grid view
Disease Research
news
Mitigating fibrotic barriers in pancreatic cancer
A human pancreatic cancer fibrotic barrier model illuminates how targeting the TGFβ/ROCK2/YAP signalling axis could enhance drug delivery.
news
Targeting drug resistance in HER2-positive breast cancer models
Researchers discovered that HER2-positive breast cancer drugs must target both HER2 and EGFR receptors to eradicate disease.
news
Investigating CWD transmission with human cerebral organoid models
Following direct exposure of human CNS tissues to CWD prions, a significant resistance to the propagation of infection was found.
webinar
Immunotherapy advancements: transforming cancer treatment
16 May 2024 | By Drug Target Review
In recent years, immunotherapy has emerged as a revolutionary approach in cancer treatment, harnessing the power of the immune system to combat cancer cells. This webinar will explore the latest advancements in immunotherapy research, highlighting breakthroughs, challenges, and future directions in the field. Participants will gain insights, including immune checkpoint…
news
Explaining sex differences in adipose insulin resistance
Heightened insulin resistance in obese men may elucidate the higher prevalence of type 2 diabetes among these individuals.
whitepaper
Poster: Assays for PRMT5, MLL4, METTL3/14, & NSP14
AptaFluor SAH: A Homogenous, Universal Assay for Histone, RNA, & DNA Methyltransferases. Case Study for PRMT5, MLL4, METTL3/14, & NSP14
article
Women in Stem with Stefanie Flückiger-Mangual
Stefanie Flückiger-Mangual, Chief Executive Officer, is one of TOLREMO’s scientific founders and an expert in drug resistance in cancer therapy. She is a biomedical scientist and biochemist by training (University of Fribourg and ETH Zurich, Switzerland) and holds a PhD in Molecular and Translational Biomedicine from ETH Zurich. She led…
news
Quantitative assessment of cerebral small vessel disease risk
Researchers discovered that measuring the concentrations of IL-18 in an individual’s blood could estimate future risk of stroke.
news
Elevated TMAO levels predict future risk of CKD
Elevated levels of trimethylamine N-oxide levels were a stronger indicator of CKD risk than the well-known risk factors.
article
Bile acids and the microbiome: revolutionising disease approaches
Thousands of bile acids have been discovered, providing new insights into how microbes influence distant organ systems.
podcasts
CRISPR/Cas: exploring its impact on gene editing
Tune in to this episode where we discuss the opportunities CRISPR/Cas technology offers to revolutionise drug discovery.
news
Uncovering the changes to β-cells at the onset of type 1 diabetes
A new study provides more clarity about the immune events surrounding the onset of T1D, including a new mechanism that could be used for β-cell protection.
news
4PY found to directly trigger vascular inflammation
Researchers have discovered a new pathway which seems to be a significant contributor to the development of cardiovascular disease.
news
Uncovering the bidirectional relationship between PD and DM
Single-cell RNA analysis provides an immunological explanation for the association between periodontitis and diabetes mellitus.
