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Novel target could improve the efficacy of treatments for renal cell carcinoma
A new study shows that upregulating the activity of the ACE2 signalling pathway in kidney cancer cells enhances the effects of clinically used treatments.
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Disease Research
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Targeting PEG2 reverses age-related cognitive decline in mice
The discovery of an inflammatory pathway promoting brain ageing and cognitive decline could lead to new treatments for age-related conditions.
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ebook: The organoid culture handbook
This tissue-specific handbook brings you key publications, in-house protocols and troubleshooting recommendations for your organoid cell culture.
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Severe symptoms of COVID-19 are caused by brain infection in mice, finds study
Researchers found that SARS-CoV-2 persists in the brain after it is cleared in the lungs and concluded the severest and longest lasting symptoms of COVID-19 may be caused by brain infection.
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Researchers discover mechanism behind severe cases of G6PD deficiency
Researchers have revealed how the most severe cases of G6PD deficiency occur, which could help scientists design new drugs for the disease.
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Recovered COVID-19 patients may be protected, but they could still transmit the virus
According to a Public Health England study, prior SARS-CoV-2 infection provides 83 percent protection against reinfection but may not stop individuals spreading COVID-19.
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Artificial intelligence analyses how viruses evade the immune system
The natural language processing model trained using viral protein sequence data was able to predict promising targets for vaccines against HIV, influenza and coronaviruses.
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New probes shine a light on the role of four-stranded DNA in human cells
A better understanding of the role of four-stranded DNA (G-quadruplex) could enhance cancer therapeutics, said the developers of the probes.
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SARS-CoV-2 infects CNS and damages brain tissue, study shows
Researchers have shown in cells and models that the central nervous system and neurons can become a target of SARS-CoV-2 infection.
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Study reveals novel targets for treating atopic dermatitis
Understanding how Staphylococcus aureus bacteria colonises skin affected by atopic dermatitis could lead to new treatments that help prevent the spread of antibiotic resistance, say scientists.
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Microbiome may influence severity of COVID-19, researchers say
A study has revealed that the microbiome could impact COVID-19 severity and may be implicated in persisting inflammatory symptoms.
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Novel human alveolar tissue model could help COVID-19 drug development
Researchers will use the in vitro model to study how respiratory viruses, like SARS-CoV-2, cause Acute Respiratory Distress Syndrome (ARDS) and develop potential interventions.
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Immune cells discovered in lungs improve flu defence, study shows
A team has found immune cells in the lungs after infection from the flu, which protected mice against reinfection from a different strain.
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SARS-CoV-2 introduced to UK more than 1,000 times before March, says genomic analysis
Researchers show that genomic tracking can be used to trace individual virus transmission lineages and could therefore be adopted for future pandemics.
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Whitepaper: Remdesivir: The technologies behind the discovery
Remdesivir is being prescribed under FDA emergency use authorisation as a treatment for patients with COVID-19.