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Disease Research

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Researchers discover how SARS-CoV-2 infects and replicates in host cells

9 November 2020 | By Victoria Rees (Drug Target Review)

A team has revealed how SARS-CoV-2 infects cells, suggesting that targeting its RNA with drugs would stop the virus replicating.

Blue antibodies surrounding a black SARS-CoV-2 particle with red Spike proteins on its surface

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Children produce a different antibody response to SARS-CoV-2 infection, finds study

6 November 2020 | By Hannah Balfour (Drug Target Review)

A new analysis reveals that the course of SARS-CoV-2 infection and the immune response it provokes is completely different in adults and children.

SARS-CoV-2 particle next to an RNA strand, all in orange on a darker orange to black gradient background

news

D614G mutation may make SARS-CoV-2 more contagious

5 November 2020 | By Hannah Balfour (Drug Target Review)

According to a new study, the SARS-CoV-2 virus is accumulating genetic mutations, including one called D614G which may have made it more contagious.

Human torso outlined in glowing blue with lungs visible and major airways outlined in pink

news

Novel therapeutic approach shows promise in mice with COPD

5 November 2020 | By Hannah Balfour (Drug Target Review)

By blocking the lymphotoxin beta receptor signalling pathway, researchers were able to prevent COPD progression and induce a full restoration of lung tissue.

news

Persistence of infected cells in lungs could explain long-term COVID-19 symptoms, say scientists

4 November 2020 | By Victoria Rees (Drug Target Review)

Researchers have found the genome of COVID-19 and infected cell syncytia in the respiratory cells of deceased patients, potentially explaining long-term coronavirus effects.

elderly woman holding hand of young doctor

news

Age may be a primary determinant of melanoma treatment resistance

4 November 2020 | By Hannah Balfour (Drug Target Review)

Scientists have shown that age may cause genetically identical melanoma skin cancer cells to respond differently to treatment, making age a primary factor in treatment response.

cartoon of a blood vessel with coronavirus particles attached to the lining of the vessel and a blood clot formed of red and white blood cells

news

Autoantibodies and over-active neutrophils may be cause of COVID-19 blood clots

3 November 2020 | By Hannah Balfour (Drug Target Review)

According to a new study, blood clots in patients with severe COVID-19 are caused by an autoimmune antibody that circulates in the blood and attacks cells.

woman scratching the back of her leg while walking on grass - idea of allergic reaction itching

news

Researchers reveal how allergens may trigger itching

2 November 2020 | By Hannah Balfour (Drug Target Review)

Certain sensory neurons and Substance P are potential drug targets for the development of novel allergy preventions or treatments, according to scientists.

shape of a human brain constructed out of red coronavirus particles

news

SARS-CoV-2 can disrupt the blood-brain barrier, find scientists

2 November 2020 | By Hannah Balfour (Drug Target Review)

Binding of SARS-CoV-2 spike proteins to the brain’s endothelial cells can cause the blood-brain barrier to become leaky, potentially causing the neurological symptoms associated with COVID-19.

news

Researchers discover novel cancer immunosuppression mechanism

30 October 2020 | By Hannah Balfour (Drug Target Review)

According to the study, the transcription factor IRF4 drives T cell differentiation and immunosuppression in multiple human cancers.

SARS-CoV-2 particles infecting a human cell

news

Lysosomes key to coronavirus shedding, finds study

29 October 2020 | By Hannah Balfour (Drug Target Review)

Scientists reveal that coronaviruses de-activate lysosomes before using them to exit infected cells and spread through the body.

news

Leveraging flow cytometry to explore COVID-19 immune responses

29 October 2020 | By Hannah Balfour (Drug Target Review)

Researchers used flow cytometry to characterise which types of T cells are involved in the immune response to COVID-19 and what they target.

cells in blue and green on a dark background

news

Cellular senescence as a drug target

27 October 2020 | By Hannah Balfour (Drug Target Review)

New research reveals that age-related declines in cellular function and proliferation occur in multiple stages, accompanied by different inflammatory responses.

whitepaper

ebook: Phenotypic screening with iPSC-derived cardiomyocytes and neurons

27 October 2020 | By Molecular Devices

Identify therapeutic effects and adverse responses to compounds earlier in the drug discovery process.

news

Analysis of mouse neuroinflammation samples aided by flow cytometry

26 October 2020 | By Victoria Rees (Drug Target Review)

A new study has highlighted the advantages of using flow cytometry for the analysis of neuroimmune cell populations from mouse models.

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