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Cellular senescence as a drug target
New research reveals that age-related declines in cellular function and proliferation occur in multiple stages, accompanied by different inflammatory responses.
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Disease Research
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ebook: Phenotypic screening with iPSC-derived cardiomyocytes and neurons
Identify therapeutic effects and adverse responses to compounds earlier in the drug discovery process.
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Analysis of mouse neuroinflammation samples aided by flow cytometry
A new study has highlighted the advantages of using flow cytometry for the analysis of neuroimmune cell populations from mouse models.
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New imaging method reveals glycan vaccine targets on HIV molecules
Using cryo-electron microscopy and site-specific mass spectrometry, researchers have mapped the glycans that shield HIV from the immune system.
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ebook: Eliminate 50/60 Hz line-frequency noise in less than one second
A major challenge within electrophysiology labs is 50 or 60 Hz line frequency electrical noise, which can either distort or completely drown out biological signal.
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On-demand webinar: Complete workflow solution from gene-to-protein
23 October 2020 | By
Our full gene-to-protein workflow can support your research for rapid protein production early during drug development so you can minimize changes from R&D to bioproduction.
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Flow cytometry market to exhibit CAGR of 12 percent
A new report has said that by 2023, the flow cytometry market will be worth $8.88 billion, partly due to an increase in stem cell research.
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Mini lung organoids reveal early SARS-CoV-2 infection process
Using lung organoids, researchers have shown that 48 hours after SARS-CoV-2 infection, the innate immune response began.
![A coiling protein 'shell,' called a nucleocapsid, shown here, surrounds Ebola's genetic material, which consists of single-strand RNA. University of Delaware researchers are simulating the way molecules of this nucleocapsid move and interact, atom by atom, to understand their functions and expose targets for anti-viral treatments [Credit: Juan Perilla Laboratory].](https://www.drugtargetreview.com/wp-content/uploads/Ebola-nucleocapsid-e1603365997854.jpg)
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The nucleocapsid as a novel drug target for Ebola virus
Using supercomputer stimulations researchers reveal that the structural stability of the Ebola nucleocapsid is depended on the presence of RNA and interactions with charged ions.
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Novel anti-inflammatory slows progression of MS in mice
When delivered intranasally, the anti-inflammatory drug VX-765 prevented axon demyelination and loss in a murine model of multiple sclerosis (MS).
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Severe COVID-19 symptoms may not be caused by cytokine storm
An analysis reveals that in comparison to other inflammatory diseases such as cytokine-release syndrome (CRS) and sepsis, the levels of cytokines in severely ill COVID-19 patients is low.
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SARS-CoV-2 also uses neuropilin-1 to infect human cells
Researchers reveal that SARS-CoV-2 is more infectious than SARS-CoV because it can use both ACE2 and neuropilin-1 to infect cells.
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Webinar: High-content analysis and phenotypic characterisation of 2D and 3D cellular models
Combining 2D and 3D models with live-cell assays allows monitoring of cell responses in real time and provides important insights about compound treatment effects, biological complexity, and physiological relevance of assay results.
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SARS-CoV-2 papain-like protease could be a novel drug target
Scientists suggest targeting the SARS-CoV-2 papain-like protease (PLpro) with inhibitors could prevent the spread of infection.
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Application note: Phenotypic characterisation of neuroactive compound effects
Learn how to perform complex analysis of calcium oscillations and assess cellular and mitochondrial toxicity.
