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Despite the promise of gene therapies, significant challenges have emerged in the field. Dr Carsten Brunn discusses the current obstacles and opportunities when developing gene therapies.
A new DNA vaccine encoding the SARS-CoV-2 Spike protein has shown promise at protecting mice and hamsters against COVID-19.
Using electrochemical detection and redox labels, researchers have created a new, faster method to sequence DNA.
Researchers have developed a technique to synthetically produce DNA oligonucleotides that avoids the degradation of phosphoramidites.
A CRISPR gene editing technique has been developed to restore dystrophin, which is missing in many Duchenne muscular dystrophy (DMD) patients.
Researchers have shown that topoisomerase TOP2A eliminates negative supercoiling, causing an increase in the number of turns of DNA strands and impacting gene expression.
Summary of a neurology publication by Alnylam Pharmaceuticals: large-scale protein screening identifies novel biomarker for onset and progression of lethal ATTRv amyloidosis.
Scientists have created a new nanopore sequencing platform that can detect the presence of the nucleobases of DNA.
Researchers have developed software that can design complex DNA nanodevices which could be used to deliver medicine while in the body.
Researchers have used CRISPR to create a new technology that can switch off almost any gene in cells, called CRISPRoff.
Researchers have shown that prime editing is able to effectively edit genes in mice but without the off-target effects of CRISPR.
An aptamer that can bind a different part of SARS-CoV-2 than known inhibitors could enhance treatments against coronavirus mutations.
A team of researchers have used microscopy techniques to monitor DNA degradation and anticancer drug release from nanostructures.
A team has demonstrated that their bioinformatics approach, PlasmidHawk, can analyse DNA sequences to identify the source of engineered plasmids.
A research team has discovered how proteins called pioneer transcription factors turn on vital genes in cells.
