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Brain cancer model developed to study glioblastoma

30 January 2020 | By Rachael Harper (Drug Target Review)

Researchers have used stem cells, CRISPR and gene sequencing technology to create the basis of a new brain cancer model that could offer opportunities for drug discovery.

news

DNA-PK identified as potential targeted therapy for cancer

28 January 2020 | By Victoria Rees (Drug Target Review)

A study has shown that the sensor of a DNA sensing pathway, DNA-PK, could act as an antiviral against tumours.

news

Study shows cheap drug could alleviate treatment-resistance in leukaemia

20 January 2020 | By Rachael Harper (Drug Target Review)

A clinical study is to be launched after researchers found that a common and inexpensive drug may be used to counteract treatment resistance in patients with AML.

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Scientists block AHR receptors to treat obesity in mice

15 January 2020 | By Mandy Parrett (Drug Target Review)

A team of scientists in the United States has successfully used a drug, which blocks AHR receptors, to prevent and treat obesity in mice. Their findings have spurred further research into the receptors’ association with diet and the gut microbiome.

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Study identifies molecules to potentially treat Plasmodium parasites

6 January 2020 | By Victoria Rees (Drug Target Review)

Researchers have discovered the most effective molecules to target DNA methylation from Plasmodium parasites, having shown success in pre-clinical trials.

news

First images of an ‘upgraded’ CRISPR tool captured

20 December 2019 | By Drug Target Review

Researchers have utilised cryo-electron microscopy and used the images they captured with an electron microscope to generate atomic resolution models of the INTEGRATE system.

news

New tool reveals DNA structures that influence disease

19 December 2019 | By Victoria Rees (Drug Target Review)

Researchers have created an algorithm that locates and analyses DNA structures which are linked to the development of certain diseases.

news

Macrophage response mechanism to pathogens revealed

18 December 2019 | By Victoria Rees (Drug Target Review)

A study has found the processes used by macrophages in their immune response, which could be used in the development of new vaccines.

news

Multi-omics approach yields novel insight for peanut allergies

17 December 2019 | By Drug Target Review

Researchers in New York have identified novel genes associated with the severity of peanut allergies and noted how these genes interact with other genes during allergic reactions. The findings could lead to better treatments for peanut allergies.

news

Antibodies could be used as nanotechnology builders

12 December 2019 | By Hannah Balfour (Drug Target Review)

Endogenous human antibodies can be used to build and dismantle 2D and 3D DNA nanostructures, finds new research.

article

How will CRISPR evolve in the future?

26 November 2019 | By Victoria Rees (Drug Target Review)

CRISPR is a tool used by researchers to precisely edit genes and has shown potential for treating genetic diseases. This article delves into some recent developments and explores what the future holds for CRISPR.

Mucin 6 gene indicates late-onset Alzheimer’s

news

Mucin 6 gene indicates predisposition to late-onset Alzheimer’s

25 November 2019 | By Mandy Parrett (Drug Target Review)

Scientists have idenified that variation in a gene called Mucin 6 appears to indicate a tendency for acquiring Alzheimer’s disease.

whitepaper

Application note: Automated Extraction of High Molecular Weight DNA

14 November 2019 | By Analytik Jena

SmartExtraction significantly simplifies the entire automated workflow of DNA extraction.

news

Enzyme involved in cancer growth imaged for first time

7 November 2019 | By Victoria Rees (Drug Target Review)

A study has revealed the structure of an enzyme that promotes cancer growth by mutating RNA, which could be used in the development of cancer treatments.

news

MaveDB: database to aid research into genetic causes of disease

5 November 2019 | By Drug Target Review

Researchers in Australia and the US have launched the first open-source database detailing genetic variants that impact human health and disease.

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