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Gene found to protect motor neurons against degeneration
Results of an international collaboration show promise for the future of motor neurone disease treatment efforts, as protective gene is identified.
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Myc gene linked to alternative splicing changes in several cancers
A collaboration of academic institutions in the United States has identified a gene that is linked to alternative splicing changes that occur in several cancers.
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New variant of the GLA gene to be linked with Fabry cardiomyopathy
A study in Finland has found a strong connection between the A143T variant of the GLA gene and increased risk of Fabry cardiomyopathy, which affects the heart, kidneys and nervous system.
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Gene editing platform improves vision in blind mice
Mice with congenital blindness have shown significant improvement in vision after undergoing a new gene therapy.
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Brain cancer model developed to study glioblastoma
Researchers have used stem cells, CRISPR and gene sequencing technology to create the basis of a new brain cancer model that could offer opportunities for drug discovery.
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DNA-PK identified as potential targeted therapy for cancer
A study has shown that the sensor of a DNA sensing pathway, DNA-PK, could act as an antiviral against tumours.
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Study shows cheap drug could alleviate treatment-resistance in leukaemia
A clinical study is to be launched after researchers found that a common and inexpensive drug may be used to counteract treatment resistance in patients with AML.
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Scientists block AHR receptors to treat obesity in mice
A team of scientists in the United States has successfully used a drug, which blocks AHR receptors, to prevent and treat obesity in mice. Their findings have spurred further research into the receptors’ association with diet and the gut microbiome.
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Study identifies molecules to potentially treat Plasmodium parasites
Researchers have discovered the most effective molecules to target DNA methylation from Plasmodium parasites, having shown success in pre-clinical trials.
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First images of an ‘upgraded’ CRISPR tool captured
Researchers have utilised cryo-electron microscopy and used the images they captured with an electron microscope to generate atomic resolution models of the INTEGRATE system.
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New tool reveals DNA structures that influence disease
Researchers have created an algorithm that locates and analyses DNA structures which are linked to the development of certain diseases.
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Macrophage response mechanism to pathogens revealed
A study has found the processes used by macrophages in their immune response, which could be used in the development of new vaccines.
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Multi-omics approach yields novel insight for peanut allergies
Researchers in New York have identified novel genes associated with the severity of peanut allergies and noted how these genes interact with other genes during allergic reactions. The findings could lead to better treatments for peanut allergies.
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Antibodies could be used as nanotechnology builders
Endogenous human antibodies can be used to build and dismantle 2D and 3D DNA nanostructures, finds new research.
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How will CRISPR evolve in the future?
CRISPR is a tool used by researchers to precisely edit genes and has shown potential for treating genetic diseases. This article delves into some recent developments and explores what the future holds for CRISPR.
