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Cancer-killing combination therapies unveiled with new drug-screening tool
Method IDs which target therapies, inadequately on their own, can be paired up to kill non-responsive cancers...
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Realising the promise of laboratory automation in biomedical research
Automation offers a choice of powerful ways to design and execute high-quality laboratory research. The use of lab automation is now pervasive in biomedical labs, offering versatile platforms on which to perform an ever‑expanding array of tasks free of human errors, and a unique means to address the problems associated…
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New DNA ‘shredder’ technique goes beyond CRISPR’s scissors
A new CRISPR-based tool that acts more like a shredder is able to wipe out long stretches of DNA in human cells with programmable targeting...
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CRISPR-Chip enables digital detection of DNA without amplification
Researchers have found multiple applications for the CRISPR (Clustered Regularly Interspersed Short Palindromic Repeats) gene editing technology since it came into use by the scientific community...
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Scientists find a cellular process that stops cancer before it starts
Salk research shows that cellular recycling process, thought to fuel cancer's growth, can actually prevent it...
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Scientists achieve the first stable simulations of DNA crystals
A study by researchers at the Institute for Research in Biomedicine has been the first to achieve stable simulations of DNA crystals...
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Molecules associated with NMDAR may be involved in schizophrenia
Genetic variants which prevent a neurotransmitter receptor from working properly have been implicated in the development of schizophrenia...
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DNA barcodes that reliably work: A game-changer for biomedical research
A new method for correcting the errors that creep into DNA barcodes has paved the way for more ambitious medical research...
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Omics-informed drug target discovery in combating emerging infectious diseases
The catastrophic consequences of ever-increasing rates of death from infectious diseases demands new experimental strategies for drug target selection and drug design. Over the last decade, the pharmaceutical industry has been wounded by several issues including failure of drug-development programmes, burgeoning cost of drug development, increasing regulatory control, lack of…
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T-cells engineered to recognise tumours expressing the CD30 protein marker
Researchers have genetically engineered immune cells to recognise and fight Hodgkin and non-Hodgkin lymphoma cells...
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New tools accurately illuminates intracellular phase separation
Researchers have made discoveries about the formation of cellular components called membraneless organelles and the key role these organelles play in cells...
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Application note: Integrated biologics – Enabling high-throughput drug discovery at Amgen with Thermo Fisher™ Platform for Science™ Software
Every day scientists are working to discover and develop new therapies and treatments to change the lives of patients suffering from serious and debilitating illnesses. Amgen Inc. has made it a priority to unlock the potential of biology to discover, develop, manufacture, and deliver innovative therapeutics to patients.
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Application note: A complete next-generation sequencing workflow for circulating cell-free DNA isolation and analysis
Circulating cell-free DNA (cfDNA) has been shown to have potential as a noninvasive substrate for the detection and monitoring of tumour cells. As circulating tumour DNA is often present at low frequencies within cfDNA, targeted sequencing is an optimal tool for mutation detection.
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scRNA-seq technique improves efficiency and accuracy of single cell RNA sequencing
Single nucleotide variations could be the key to better identification of tumour subpopulations...
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Scientists pinpoint mechanism by which mutant p53 protein promotes cancer
Scientists in Australia have discovered how the most important gene in preventing cancer, TP53, is hampered in its tumour-fighting efforts by mutant p53 proteins.