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Droplet Digital PCR detects and quantifies cancer mutation
Two ddPCR-based assays were developed to detect the two mutations in the promoter region of the TERT gene, which could be used as biomarkers...
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Chromatin study unearths link between DNA-protein binding and cancer
A team of scientists led by Stanford University School of Medicine has identified a link between how proteins bind to our DNA and how cancer develops. This finding may allow researchers to predict cancer pathways and long-term patient outcomes.
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GFAP gene mutation creates tangles in brain cells – cause of neurological disease
A recent study in the U.S. has identified how a mutation in the GFAP gene, which encodes for the GFAP protein, causes the tangles in brain cells associated with Alexander disease and may also impact other neurological diseases.
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Protein sequencing method could transform biological research
A team of researchers have demonstrated a new way to sequence proteins that are much more sensitive than existing technology, identifying individual protein molecules rather than requiring millions of molecules at a time
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Novel DNA vaccine offers broad protection against Influenza-A H3N
Researchers developed a novel DNA influenza vaccine based on four micro-consensus antigenic regions selected to represent the diversity of seasonal H3N2 viruses...
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Key genomic differences in breast cancers of women of different ethnicity
Study of genomic data from breast cancers of Nigerian women, compared with American women, highlights significant differences that may help targeted treatment for the epidemic across Sub-Saharan Africa.
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DNA vaccine shows promise for cancer immunotherapy
DNA vaccine optimised to cross-react with several MAGE-A isoforms generates a robust immune response and antitumour activity in a pre-clinical model of melanoma...
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Mitochondrial diseases could be treated with gene therapy
Researchers have developed a genome-editing tool for the potential treatment of mitochondrial diseases...
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Scientists develop means to manipulate nuclear pore numbers
Researchers in California have developed a method to facilitate control of nuclear pore numbers in cells. The capability is expected to glean valuable information to aid cancer treatment.
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Class of neurological disorders share 3D genome folding pattern
Researchers have found another common thread linking nearly all of the TNR expansion diseases...
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Unique method to find cancer mutations offers chance of improved treatment
Researchers have condensed methods for identifying cancer gene mutations in cells into a single process, to aid understanding of tumours and improve treatment outcomes.
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Carving a pathway toward personalised cancer therapy
Individualised therapies that target the specific genetic features of tumours have the potential to transform cancer diagnosis, treatment and care. However, several challenges remain before these approaches can be widely used in the clinic.
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Viral DNA mechanism discovery could lead to improved infection control
A new study reveals a previously unknown mechanism that governs whether viruses that infect bacteria will quickly kill their hosts or remain latent inside the cell.
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CRISPR technique skips over portions of genes that can cause disease
Researchers have adapted CRISPR to cause the cell's internal machinery to skip over a small portion of a gene when transcribing it into a template for protein building...
