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New algorithm can predict diabetic kidney disease
Researchers from US and Hong Kong have found that a simple blood sample may help doctors catch kidney disease earlier in type 2 diabetes patients
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Novel approach stimulates DNA repair mechanisms to combat a leading cause of autism spectrum disorders
US researchers report promising results for fragile X syndrome, by stimulating cells' DNA repair mechanisms that could correct the inherited genetic defect associated with the disorder.
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New study uncovers DNA repair mechanism in bacterial cells
US research reveals mechanism used by bacterial cells to repair their faulty DNA, which could help scientists understand the intricacies of DNA repair processes.
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CRISPR and single-cell sequencing highlight genetic variants for traits and diseases
This article highlights a new approach to address human genetics, using STING-seq which provides roadmap to identify variants and genes, enabling deeper understanding of the noncoding genome and targets for therapies
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Chances of eliminating HIV infection increased by dual gene-editing method
US researchers suggest that combing a dual gene-editing approach with antiretroviral drugs can eliminate HIV infections in animal models.
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Blocking a microRNA may prevent age-related conditions
Conditions like chronic inflammation, muscle loss and bone loss have an elevated microRNA, US researchers attempted to block this in aged mice.
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Stem cell discovery has potential to impact cancer treatments
A team from Trinity College Dublin have uncovered mechanisms that stem cells use to establish cellular identity, a process that will have potential in cancer and targeted treatments.
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Analysis of 33 tumour types identifies new immunotherapy targets
The researchers identified 1,068 transposable element-derived transcripts with the potential to produce tumour antigens that could serve as targets for new immunotherapies.
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First molecular therapeutic for Angelman syndrome to advance into clinical trials
The scientists from Texas A&M have developed GTX-102, a novel therapeutic candidate to target Angelman syndrome by reactivating expression of deficient protein.
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The future for quality control of mRNA medications
Japanese researchers combine cutting edge mass spectrometry with software analysis to elucidate mRNA structure.
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Understanding molecular mechanisms behind breast cancer
Oestrogen receptors play a crucial role in breast cancer. By making them therapeutic targets, oestrogen can be regulated with the aim to prevent breast cancer.
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What do cancer cells crave?
US researchers uncover the amino acid: arginine, that prompts genetic mutations in cancer cells.
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Researchers develop novel method to insert large DNA sequences more accurately in cells
The scientists say that the engineered CRISPR enzymes could overcome key limitations for eventual use to treat genetic diseases irrespective of a patient’s particular mutation.
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New system for safer CRISPR-based gene drive testing and development
US researchers outline the development of a new system for testing and developing CRISPR-based gene drives in the laboratory, and safely converting them into tools for potential real-world applications.
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Novel protein coordinates melanin production
Japanese researchers reported that a key transcription factor “Nrf3” regulates the process of melanin production in mouse and human cells.
