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New machine learning model could encode words to kill cancer cells
US researchers, using new machine learning techniques have developed a virtual molecular library of “words” that encode commands to kill cancer cells.
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Drug Development
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New ALSV virus discovered in Swiss ticks
Researchers have detected Alongshan virus (ALSV) for the first time in Switzerland in ticks.
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Drug Target Review – Issue 4 2022
A new Drug Target Review issue is now ready to download! This issue features articles which explore how artificial intelligence can enhance screening and ways to find new hits through simultaneous orthogonal screens. Also included are articles on CRISPR, immuno-oncology and RSV vaccines.
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What parts of a tumour are linked to muscle wasting?
US researchers found that the severity of muscle wasting from cancer is related to the type, size and location of the tumour, in mice.
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Genetic cause of ALS and dementia repaired by RNA-targeting strategy
US scientists have developed a potential medication for the genetic cause of ALS and dementia, that eliminates the mutated segments of RNA.
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Biovac and IVI sign ground breaking deal for the manufacturing of OCV
Biovac signs deal with IVI to develop and manufacture oral cholera vaccine (OCV) for African and global markets.
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Novel ‘prodrug’ designed to eliminate cancer without harming healthy cells
US researchers discovered in a study in mice that augmented drug eliminates cancer cells without causing toxicity.
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New MACHETE technique developed to slice into cancer genome
Sloan Kettering Institute (SKI) researchers have developed a new machete technique to slice into the cancer genome and study copy number alterations.
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Five recent CRISPR drug target discoveries
This article highlights five of the latest findings revealed using CRISPR that could be used in the development or design of new therapies.
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Probiotic ‘backpacks’ show promise for treating IBD
US researchers have uncovered the uncapped potential that gut-friendly bacteria has for improving treatments of inflammatory bowel disease (IBD).
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SARS-CoV-2 blocked by antiviral substances discovered in South Korean plants
South Korean researchers identified two saponins there were highly effective in blocking the ability of SARS-CoV-2 variants to enter cells.
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Fentanyl vaccine potential ‘game changer’ for opioid epidemic
A study has suggested that a new vaccine could prevent fentanyl from entering the brain, after showing success in rats.
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Green tea and resveratrol could be the next step for Alzheimer’s disease research
US researchers, using a 3D neural tissue model, found that compounds from green tea and resveratrol could diminish Alzheimer’s amyloid plaques in lab tests, with no side effects.
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Pacemaker channel discovery could lead to better heart drugs
The research has shown in high-resolution detail how certain lipids interact with pacemaker ion channels to enhance their activity.
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Potential secret of viral resistance unlocked
Trinity researchers have discovered the secret to viral resistance, by screening women exposed to HCV.
