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Tuberculosis vaccine shows efficacy in pre-clinical trials
Australian researchers have demonstrated the success of a novel TB vaccine in mice, which could provide another treatment option for the disease.
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Drug Development
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Breast cancer ‘sleeper cells’ could be formed after drug treatment
Breast cancer medicines may force some cancer cells into 'sleeper mode', allowing them to potentially come back to life after treatment.
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What are the pros and cons of using organoids?
Dr Shona Lang investigates the advantages and disadvantages of using organoids within R&D, highlighting the most important questions to ask before using these models.
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Blocking new protein helps immune system to fight cancer
A protein discovery could lead to a new and highly potent immune-therapeutic drug for the eradication of cancers using natural killer cells.
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Collaboration to discover MND treatments announced
MSD and the Francis Crick Institute will work together on a project to identify disease targets for motor neuron disease.
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Sickle cell drugs could be tested with help from new computer model
New computer model that simulates the way red blood cells become misshapen by sickle cell disease could identity promising drug candidates.
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Applying AI language translation to the creation of new pharmaceuticals
Designing new drug molecules is crucial to R&D. Dr Sam Genway suggests that one way to improve and speed up this process is using AI inspired by language translation.
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Process for rejuvenating aged rat brain stem cells discovered
A research team has developed a method for regenerating old brain stem cells from rat models, which could be used to treat age-related brain diseases.
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‘Ubiquitin clipping’ proteomics technique could be used as novel treatment
A new technique called ‘ubiquitin clipping’ has been created which could aid proteomics research and the development of new drugs for ubiquitination.
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Five newest developments for imaging in drug research
Imaging methods are used by scientists to identify therapeutic targets and improve drug efficacy. This article lists five of the latest developments for imaging techniques.
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Experimental compound could be used to treat pancreatic cancer
Using a compound called PTC596 in combination with other drugs, researchers effectively treated pancreatic cancer in mice.
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New model predicts cognitive decline two years ahead
Researchers hope the system can choose the right patients to enroll in clinical trials, to speed discovery of drug treatments.
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New system enables improved pre-clinical testing of heart drugs
Researchers have extended the life of heart segments from 24 hours to six days, enabling pre-clinical trials to experiment on these new models for longer periods of time.
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Treatment for Lafora disease shows promise in pre-clinical study
A novel antibody-enzyme fusion therapeutic strategy for Lafora disease has shown effectiveness in pre-clinical study mice models.
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Models should be in social conditions for pre-clinical trials, study finds
A study has shown that mice and rats become stressed when housed alone, affecting results of pre-clinical trials.