news
Cancer cells hide to evade immunotherapy
Cancer cells have been found to evade immunotherapy by hiding behind human leukocyte antigens, with researchers identifying therapies to prevent relapse...
List view / Grid view
Drug Development
article
Mass spectrometry and drug development – how the two come together
Since the development of the so-called soft ionisation techniques: electrospray ionisation and matrix-assisted laser desorption and ionisation in the 1980s and early 1990s and the development of high-resolution mass spectrometers, mass spectrometry (MS) has come to the fore in studying complex biological systems...
news
A universal flu vaccine may be in sight
Researchers from Oxford have identified the initial steps on the path towards creating a universal influenza vaccine that could last for life...
news
Amyloid beta – a good therapeutic target?
Phase III clinical trials for a drug targeting amyloid beta plaques are underway, with results expected in the next two to three years...
news
Dietary fibre could be key to prevent age related decline in brain functions
Researchers have identified that dietary fibre could be beneficial for older people, to prevent inflamed microglia leading on to cognitive disorders...
news
Method developed to facilitate effective protein drugs with fewer side effects
Researchers in Denmark have developed a method that enables better tailored pharmaceuticals with fewer side effects.
article
Synthetic biology in drug discovery
Synthetic biology is broadly defined as the design and construction of novel artificial biological pathways, organisms or devices; or the redesign of existing natural biological systems.1 It brings together a range of disciplines and skills, from biology and chemistry to computing, bioinformatics and engineering.
article
Expert view: Challenges in flow cytometry
Flow cytometry is a powerful and flexible technology that delivers high content information from single cells and particles. Flow cytometry lends itself to a wide variety of applications, but traditional flow cytometry technologies are not widely adopted in the drug discovery industry due to limited throughput, slow sampling speeds and…
news
Non-antibiotic drug developed to treat TB
Scientists at The University of Manchester have developed the first non-antibiotic drug to successfully treat tuberculosis in animals...
news
A new generation of pain relief
Researchers have developed a new generation of pain relief drugs that only target the affected area, with the help of computer simulations...
article
The rise of high-throughput flow cytometry in drug discovery
Flow cytometry has played a key role in drug development, largely due to its ability to measure up to twenty parameters on single cells or particles suspended in a fluid stream. Typically, cells are labelled with fluorescent markers and passed through a series of lasers, after which the resultant fluorescent…
article
Applications of high content screening in autophagy
Autophagy is an important process to maintain cellular homeostasis and function.1 Basal levels of autophagy are essential for most cells to remove unwanted protein aggregates and damaged organelles in order to prevent diseases.2 However, sometimes cells are unable to maintain physiological stability as a consequence of altered autophagy, which leads…
news
Antibody-based approach to destroy deadly ovarian cancer
Researchers are developing an antibody-based approach to destroy deadly ovarian cancer -- an approach that could also be modified to kill breast, prostate and other solid tumours...
news
Scientists discover over 7,000 effective antibiotic combinations
Researchers discovered effective antibiotic combinations using four or five drugs, despite claims that combinations of three or more won't work...
news
Cannabidiol shows sustained effects against depression
Researchers have found that a single dose of cannabidiol in rats with symptoms of depression was highly effective at eliminating symptoms...