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New drug has potential to turn COVID-19 virus against itself
The Scripps Research team showed that a variation of an already FDA-approved therapeutic for neurological disease can block COVID-19 infection in animals.
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Drug Discovery Processes
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New scientist at Rockefeller University plans to unlock vast chemical spaces for drug discovery using algorithms
Jiankun Lyu hopes to use algorithms to find improved drugs by screening chemicals that may look different to a protein’s known ligands but work in a similar way.
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AI-based screening method could boost speed of new drug discovery
Using an AI algorithm that models drug and target protein interactions, researchers achieved up to 97 percent accuracy in identifying promising drug candidates.
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Right model, right complexity: using in vitro human disease cell models in drug discovery
Ensuring that drug candidates can reach the clinic is no easy task, so having models that can closely represent human pathology is crucial. Here, Dr Beth Hoffman, CEO of Origami Therapeutics, describes the successes and challenges of using human disease cell models in drug discovery.
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X-ray screening identifies compounds that block a major coronavirus enzyme
A new screening study has shown that three natural compounds present in foods like green tea may be candidates for drugs that combat the coronavirus.
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New machine learning technique to accelerate the process of drug screening
Researchers have developed a machine learning method to quantitatively analyse and compare microscopy images of proteins.
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The hunt for new hepatitis treatments
In this exclusive interview for World Hepatitis Day with Drug Target Review, Professor Ziv Ben Ari from the Sheba Medical Center discusses recent progress towards hepatitis treatment.
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Potential target for type 1 diabetes treatment
Researchers have discovered a new pathway to the regeneration of insulin in pancreatic stem cells, findings that could move towards new therapies for type 1 and type 2 diabetes.
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Scientists discover an antibody that potentially acts as a therapy against SARS-CoV-2
The scientists found that the neutralising monoclonal antibody protected against SARS-CoV-2 infections in animal experiments.
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Researchers create weakened version of SARS-CoV-2 that does not cause illness or death
Scientists have received approval to work with a weakened, non-harmful version of SARS-CoV-2 in biosafety level 2 laboratories, which makes it more efficient to study the virus, and to identify new treatments.
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The potential of Ayurvedic medicine
In a recent study, scientists have highlighted the possible use of South Asian medicine, specifically, Ayurvedic medicine, to treat type 2 diabetes. In this article, Drug Target Review dives into the study’s implications and what it means for the western world of drug discovery.
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New £4.25 million grant kick starts UK-wide collaborative research effort to end motor neuron disease
A £4.25 million research grant has been awarded seeks to discover meaningful MND treatments within years.
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Repurposed drug inhibits enzyme related to COVID-19
Researchers have found that an already existing drug compound could block the activity of a key enzyme of COVID-19.
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Miniaturising organoid drug screens using nanofibrillar cellulose hydrogels
Drug testing on advanced cell-based models such as organoids has gained in popularity, but significant technical hurdles remain that prevent further assay miniaturisation and higher assay throughput. Through the replacement of animal-derived basement membranes with wood-derived nanofibrillar cellulose hydrogel (NFC), Dr Tijmen Booij and Dr Christian Stirnimann from ETH Zurich,…
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A mathematical algorithm to network complex drug interactions
Researchers used mice to develop a mathematical algorithm of a heart attack.