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Three molecules show promise as epilepsy treatments in pre-clinical trials
Researchers have synthesised three oligonucleotide inhibitor molecules which stopped seizures in mouse models, making them potential epilepsy drugs.
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Drug Discovery Processes
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Imaging In-Depth Focus 2020
The articles in this in-depth focus discuss the difficulties in deciding what information to capture when imaging three-dimensional (3D) cell models and the use of non-invasive imaging techniques to discover small molecule drugs to control protein translation.
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Chromatography and bioassays used to detect bioactive compounds in plants
Bioassays and thin-layer chromatography has been used by scientists to analyse molecules in plant extracts as a fast and cost-effective method for identifying new drug compounds.
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Laboratory automation in early drug discovery
The future of drug discovery lies in an automated world where the workflows for biological assays, chemical synthesis and data analysis are connected by flexible, mobile and modular hardware, integrated with software solutions that will interface with scientists for increased efficiency and productivity (the realisation of Industry 4.0). This article…
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Researchers to screen compound library for antiviral drugs to combat COVID-19
Scripps Research has announced it will screen over 14,000 compounds to see if any present significant activity against COVID-19, for use in a therapeutic.
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New drug discovery centre with screening capabilities opens in Australia
The National Drug Discovery Centre (NDDC) has opened in Australia, with support from the government to subsidise the screening of medicinal compounds.
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Discovering and designing drugs with artificial intelligence
The first drug designed using artificial intelligence (AI) has moved into its Phase I trial. Professor Andrew Hopkins of Exscientia explains how an algorithm was used to achieve this milestone.
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Rebalancing the immune system to treat autoimmune disease
Dr Nicolas Poirier reveals how immunotherapies can be designed to recalibrate the immune system for long-term maintenance of autoimmune remission.
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2020: Reset your expectation for surface plasmon resonance (SPR)
25 February 2020 | By Bruker Daltonics
Learn about the latest software tools for Bruker Daltonic’s SPR instrumentation and explore high-throughput screening strategies enabled by their ecosystem.
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Case Study: Optimising upstream bioprocessing in cell line development
Read how Cyto-Mine® has helped improve overall efficiency and productivity in cell line development at FUJIFILM Diosynth Biotechnologies.
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ebook: Accelerating antibody discovery
Hybridoma-based antibody discovery: the challenges and how to overcome them using microfluidic picodroplet technology.
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Application note: Evaluation of hepatic function in 3D culture
In vitro evaluation of hepatic function using a primary human hepatocyte 3D spheroid culture system
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Application note: Hypoxia measurements in live and fixed cells
Hypoxia measurements in live and fixed cells using fluorescence microscopy and high-content imaging
news
Researchers develop screening platform to detect new antibiotics
A new technology developed by scientists combines small molecule screening methods with machine learning algorithms to identify novel antibiotics that inhibit ribosomes.
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Faster drug discovery could hit ‘undruggable’ targets
A new technique has been developed which has the potential to harness bacteria to produce billions of different drug candidates to treat diseases like cancer.
