news
Freeze-dried vaccine may help eradicate polio
Researchers have developed a polio vaccine that doesn't require refrigeration, meaning it could someday be used all over the world...
List view / Grid view
Drug Discovery Processes
news
Transporting proteins into cells to mitochondria
J-proteins such as Xdj1, as helpers of the heat shock protein 70 chaperones, and were found to be involved in the transport of proteins to the mitochondria...
news
Stopping cancer cells in their tumour ‘highways’
Using controlled network microenvironments, tumour cells were prevented from travelling, which could prevent spread of the cancer throughout the body...
whitepaper
Application note: Cellular dopamine and intracellular calcium signaling using the next generation HTS microplate reader
This application note highlights the direct optic bottom reading performance of the BMG LABTECH microplate readers in two different cell-based fluorescence intensity assays from Invitrogen.
webinar
High throughput screening for deep mining of antibody repertoires, Dr. Stefan Moese, Novartis, Switzerland
9 November 2018 | By Beckman Coulter
In this webinar you learn about a high throughput screening approach for mining of antibody repertoires in the context of biologics drug discovery.
news
Disrupting quinolones to prevent antibiotic resistance
Disrupting the communication between bacteria and quinolone signalling can inhibit the the production of toxins and virulence factors...
news
P2K system could resolve bottlenecks in drug research
Researchers have developed a new system that could significantly speed up the discovery of new drugs and reduce the need for costly and time-consuming laboratory tests...
webinar
Harmonising drug-target binding data analytics on a single platform
6 November 2018 | By PerkinElmer
This webinar outlined the fundamentals of a design process where an experimental analytics data workflow is being integrated into a more seamlessly interactive platform...
news
Charles River to present collaborative methods at Neuroscience 2018
Charles River Laboratories International, Inc. (NYSE: CRL) announced that its team of neuroscience drug discovery experts will present 26 scientific posters, both independently and collaboratively with clients, at Neuroscience 2018, the 48th annual meeting of the Society for Neuroscience (SfN)...
news
Charles River and Distributed Bio enter exclusive partnership to create an integrated antibody discovery and development platform
Charles River Laboratories International, Inc. announced that it has entered into an exclusive partnership with Distributed Bio, Inc., a leader in the computational design and optimisation of antibody discovery platforms...
news
Biomarkers to detect and prevent liver cancer
An increase in the expression of sugar-burning 'glycolytic' enzymes in precancerous cirrhotic livers has been identified and could be used as a biomarker...
webinar
Compliance with data integrity and computerised system validations
30 October 2018 | By PerkinElmer
During this webinar, we investigated trends seen globally for data integrity violations and avenues for remediation.
webinar
Cell-based and biochemical high-throughput screening in 1536-well plates
30 October 2018 | By BMG Labtech GmbH
In this webinar, we presented two examples of HTS in 1536-well plates, a screen for protein-protein interactions and a cell-based luciferase reporter assay.
webinar
Integrated fragment-based approach reveals enzymatic inhibitors with potential therapeutic application
25 October 2018 | By NanoTemper Technologies
In this webinar, speakers presented results of integrated fragment-based approaches that have led to the discovery of the first ligands of IDO1 that are able to modulate non-catalytic signalling functions of the enzyme...
news
Protein adhesion complex cell structure identified
A cell structure identified has given an insight into how cells attach to their surroundings, and could be used to discover potential actions of new drugs...