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Application note: Distinguishing cell types by phenotypic profiling
Describing how a single nuclear stain can enable phenotypic profiling for new and additional perspectives on assays at no extra cost.
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Drug Discovery Processes
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Tech note: Benefits of water immersion lenses for HCS
Water immersion lenses provide: brighter images from HCS samples; faster and gentler imaging; higher quality images from both 2D and 3D samples.
news
HIV-1 genetic diversity is higher in vaginal tract than in blood during early infection
New evidence supports the existence of genetic 'sieve' on the path from vaginal tract to bloodstream...
news
G-CSF protein involved in cocaine addiction
Researchers have identified a protein produced by the immune system that could be responsible for the development of cocaine addiction...
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Blood-vessel-on-a-chip provides insight into new anti-inflammatory drug candidate
Researchers have discovered that synthetic APC-mimicking molecules provide anti-inflammatory and anti-thrombotic protection to endothelial cells without interfering with blood clotting...
webinar
The kinetics of drug binding
15 January 2018 | By BMG Labtech GmbH
Optimising the receptor binding kinetics of new drugs can have significant benefits, ranging from improved duration of action to enhanced efficacy through the insurmountable antagonism of dynamic physiological systems.Despite this, the kinetics of new receptor ligands are rarely measured early in the drug discovery process, largely because current assays are…
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Scientists develop green fluorescent protein to aid intracellular research
Researchers at Osaka University in Japan have developed a superior acid-tolerant green fluorescent protein to enhance the study of intracellular molecular dynamics.
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Anti-obesity drug shrinks fat without suppressing appetite
Researchers have discovered a drug that has been shown to selectively shrink excess fat by increasing fat cell metabolism...
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Application note: Functional GPCR studies using AlphaScreen cAMP Detection Kit
In this application note, PerkinElmer demonstrates the ease and utility of the AlphaScreen® cAMP assay for detecting both agonist and antagonist-induced cAMP responses within cells.
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Application note: LANCE Ultra TR-FRET – based detection and modulation of Phosphorylated STAT3 levels in human cells
In this application note, PerkinElmer demonstrates how LANCE® Ultra, a homogeneous assay format, can be used to quickly and accurately assess modulation of pSTAT3.
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Rational drug design: How far have we come?
From the early use of Hansch parameters and Topliss Trees to today’s computational structure–activity techniques, medicinal chemists have long sought to rationalise drug design to find the quickest and most resource-efficient route to market. But while modern strategies are more reliant on statistical algorithms and vast data libraries, these founding…
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Application note: Fc-Receptor binding in ADCC assays utilising LANCE Ultra Technology – characterisation of hIGs and FcγRIIIa
In this application note, PerkinElmer demonstrates the ease and utility of using LANCE® Ultra, a homogeneous assay format, for determining binding profiles of therapeutic monoclonal antibodies to FcγRs.
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Application note: High throughput quantitation of cytokine biomarkers using LANCE Ultra TR-FRET assays
In this application note, PerkinElmer demonstrates the sensitivity, robust performance, and HTS suitability of the LANCE Ultra cytokine biomarker kits.
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Application note: Development and utilisation of bromodomain and extra terminal domain (BET) assays using AlphaLISA technology
In this application note, PerkinElmer demonstrates the ease and utility of using AlphaLISA®, a homogeneous assay format, to screen for small molecular inhibitors of BET bromodomains.