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AI-based screening method could boost speed of new drug discovery
Using an AI algorithm that models drug and target protein interactions, researchers achieved up to 97 percent accuracy in identifying promising drug candidates.
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Drug Discovery
In the fields of medicine, biotechnology and pharmacology, drug discovery is the process by which new candidate medications are discovered.
whitepaper
Application note: Fast-track antibody discovery: a high-throughput method for identifying and isolating rare secreting cells
Discover how picodroplet microfluidic technologies can identify and isolate 'hit' cells, quantify varying concentrations of antigen-specific antibodies and much more.
article
Right model, right complexity: using in vitro human disease cell models in drug discovery
Ensuring that drug candidates can reach the clinic is no easy task, so having models that can closely represent human pathology is crucial. Here, Dr Beth Hoffman, CEO of Origami Therapeutics, describes the successes and challenges of using human disease cell models in drug discovery.
article
A high-throughput macrodomain assay to identify coronavirus drugs
In the search for a rapid, easy way to identify drugs to fight SARS-CoV-2, researchers from across the US came together to develop and apply a high-throughput ADP-ribosylhydrolase assay, ADPr-Glo. Here, Dr Veronica Busa and Dr Anthony Leung from Johns Hopkins University describe the ADPr-Glo assay and how it can be…
news
High-throughput screening reveals compounds that inhibit SARS-CoV-2 replication
Researchers have used a high-throughput assay to screen for potential small molecule SARS-CoV-2 replication inhibitors.
news
Cancer immunotherapy drug discovery outsourcing size to increase globally
A report has shown that the immuno-oncology drug discovery outsourcing market is set to be worth $2563 million by 2030.
news
Screening reveals modulators of macrophage training and SARS CoV-2 infection
Researchers screened biologically active small molecules, finding several compounds with the ability to induce training effects on macrophages.
news
Global high-content screening market set to be worth $2.52bn by 2030
A report has found that rapidly evolving R&D infrastructure will help to drive the high-content screening market forwards.
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Drug Target Review Assays ebook 2022
Included in this ebook are pieces on how an assay for the detection of sepsis was developed and a new high-throughput assay that could reveal new drugs to fight COVID-19.
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Drug Target Review – Issue 3 2022
In this issue are articles on synthetically engineered bacteria to deliver therapeutics, how single-molecule fluorescence resonance energy transfer was used to image GPCRs and a new assay to identify coronavirus drugs. Also included are pieces on vaccine development, monoclonal antibodies and neuroscience.
news
Luminescent sensor could enable high-throughput screening in presence of fluorescence
A bioluminescence resonance energy transfer sensor has been developed to report changes in intracellular Ca2+ concentrations during screening.
news
Researchers discover compound that could treat Chagas disease
Using screening techniques, researchers have identified the compound called AN15368 which works as an antiparasitic against Chagas disease.
news
X-ray screening identifies compounds that block a major coronavirus enzyme
A new screening study has shown that three natural compounds present in foods like green tea may be candidates for drugs that combat the coronavirus.
podcasts
Episode 12 – ELISA assays with Dr Ana Miletic and Anna Dey, Kyowa Kirin & Dr Cathy Olsen, Molecular Devices
In this episode, experts discuss how they use ELISA assays in their research as well as the specific benefits of this kind of immunoassay.
news
Molecular Devices and HeartBeat.bio announce collaboration to automate and scale cardiac organoids for high-throughput screening in drug discovery
Molecular Devices has announced a collaboration with HeartBeat.bio to develop cardiac organoids for use in drug discovery.