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Immunotherapy and DNA damage repair combo could target lung cancer
Combination therapy with a CHK1 or PARP inhibitor, with an immune checkpoint inhibitor caused the regression of small cell lung cancer in all mice treated...
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Drug Discovery
In the fields of medicine, biotechnology and pharmacology, drug discovery is the process by which new candidate medications are discovered.
webinar
Phenotypic screening using iPSC-based human disease biology
18 February 2019 | By Tecan and Ncardia
Ncardia, will discuss the application of human iPSC-derived cell-based assays and high throughput screening for drug discovery and development.
news
Live-imaging technique reveals cellular plug for leaky bio barrier
A microscopy assay has shown the repair mechanism involved in the activation of a protein called Rho, used to plug leaky biological barriers in the body...
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Reprogramming stem cells using the measles virus vector
A method has been developed to reprogram stem cells using the measles virus vector, cutting a four-step process to only one stage...
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Reversible antiplatelet therapy fights cancer metastasis and clotting
A novel antiplatelet therapy could help to prevent heart attacks and stroke through preventing the formation of blood clots...
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Development of a gel for liver cell culture on microchips
Hydrogels could be used to build organs on chips to test potential medications, with the aim that they could potentially replace animal studies...
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Efficacy of breast cancer therapy measured using PET imaging
Researchers have developed a method using PET imaging along with 18F-fluorofuranylnorprogesterone to analyse the efficacy of breast cancer treatments...
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Diagnostic technique reveals biomarker differentiating bladder cancer from inflammation
A biomarker that can differentiate between chronic cystitis (inflammation of the bladder) and a non-muscle invasive-type blood cancer could aid diagnosis...
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Genomic approach to studying widespread malaria
Researchers have suggested that the most widespread human malaria parasite could be studied and possibly treated using genomics...
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Protecting vision after optic nerve trauma using arginase 2
Arginase 2 could be used as a drug target target to protect vision after optic nerve trauma, as removal of this enzyme decreases retinal neuron death...
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Functional transplantable B-cells generated from mice
Stem cells generated from mice have shown to be functional when transplanted, leading to the possibility of future therapies...
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Protection against Mayaro virus using engineered DNA vaccine
An engineered DNA vaccine that induces a robust and specific immune response against the disease, also provides complete protection...
article
Hit-to-lead discovery at a nonprofit research institute
Small molecule drug discovery has long been the domain of pharmaceutical companies, and that’s not likely to change anytime soon. But there’s a cadre of universities and nonprofit research institutes that have embraced drug development at its earliest stages, in some cases identifying and optimising compounds that target possible disease-driving…
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The role of immune cells in metastasis
Specific immune cells, such as neutrophils, have been found to aid the progression of cancers, promoting metastasis in tumours...
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Virtual drug discovery tackles unknown universe of drugs
An online compound library consisting of the structure of over a billion molecules could be the future of drug discovery...