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In the fields of medicine, biotechnology and pharmacology, drug discovery is the process by which new candidate medications are discovered.
Many drugs fail in clinical trials due to toxicity-related issues; therefore, drug-mediated cellular toxicity should be determined at an early stage in the drug discovery value chain. There are many assay systems that can be utilised to measure cellular toxicity. In this article we demonstrate that intracellular ATP concentrations are…
Manchester University researchers have developed a high-throughput platform to analyse and study a family of enzymes that are linked to cancer...
There is substantial interest in the scientific community in using human induced pluripotent stem cell (hiPSC)-derived neural cells to study basic mechanisms of brain development, neuronal function, and drug-induced effects. In vitro-generated brain organoids are promising models, because they show a remarkable degree of maturation and can be kept in…
Every day scientists are working to discover and develop new therapies and treatments to change the lives of patients suffering from serious and debilitating illnesses. Amgen Inc. has made it a priority to unlock the potential of biology to discover, develop, manufacture, and deliver innovative therapeutics to patients.
Many bioanalytical labs work with a crowded and siloed set of systems and processes. From part electronic to part paper-based workflows to standalone point-solutions, the result is a lack of insight into data and slower reporting and results handling.
Drug target identification has a key role in the drug discovery value chain. A critical step in the development of pharmaceuticals is identifying the direct targets of potential drug candidates as well as distinguishing any secondary or off-target effects...
UCLA-led research has shown how using electron microscopes to analyse small molecules coud be beneficial in speeding up the drug discovery process...
A recently discovered enzyme could lead to the development of a treatment where cancer cells are starved of 'food' provided by this protein...
DNA gyrase, a molecular machine used to prevent DNA from coiling, could be used to ensure bacterial DNA coils, reducing the risk of infection to humans...
A study by Princeton Radiology researchers has found that cryoablation could be effective in targeting low risk breast cancer...
The relative failure of molecular target-based drug discovery has led to a return to phenotypic screening. Targets that are intracellular necessitate their drug ligands to pass through plasma membranes, where the protein:lipid ratio is often 3:1 by mass and at least 1:1 by area. The widespread view that most of…
J-proteins such as Xdj1, as helpers of the heat shock protein 70 chaperones, and were found to be involved in the transport of proteins to the mitochondria...
Mouse models used to show how convection enhanced delivery caused glioma cells to invade the rest of the brain could help to prevent this spread in future...
A study conducted by researchers at The University of Manchester and Manchester Children's Hospital has revealed 35 genes linked to chronic kidney disease...
Using controlled network microenvironments, tumour cells were prevented from travelling, which could prevent spread of the cancer throughout the body...
