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Novartis and UC Berkeley collaborate to tackle ‘undruggable’ disease targets
Collaboration aims to unlock difficult drug targets and accelerate the discovery of new medicines in areas such as infectious diseases and cancer...
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Drug Discovery
In the fields of medicine, biotechnology and pharmacology, drug discovery is the process by which new candidate medications are discovered.
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Parkinson’s UK Drug Discovery Manager joins DTR advisory board
Drug Target Review welcomes Janusz Kulagowski to its advisory board ...
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Potential therapeutic protein inhibitors for Chagas disease
Researchers have used a multi-modal integrated approach to develop potential new anti-Chagas therapies...
whitepaper
Application note: Application of MultiCyt QBeads for high throughput cytokine profiling in human peripheral blood mononuclear cells
In this application note IntelliCyt Corporation report on the development and validation of their family of MultiCyt QBeads for the detection of cytokines in a high-throughput screening application on the iQue Screener...
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Structure based drug discovery facilitated by crystallography
Drugs exert therapeutically meaningful effects if they bind with appropriate selectively and potency to their respective targets. Although many of the assay techniques employed in early-stage drug discovery provide evidence that a drug is acting upon the target under investigation, this is often indirect and the site of action and…
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Expert view: A technological breakthrough in flow cytometry
Flow cytometry has become a widely used technology in life science research. It is also essential for many pharma and biotechnology companies due to its proficiency in identifying biomarkers, developing biopharmaceuticals, and assessing the efficiency of new pharmacological protocols...
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Expert view: Single-cell sequencing in basic research and clinical applications
Next-generation sequencing (NGS) has greatly increased our understanding of biological phenomena and human disease. In particular, single-cell sequencing is one of the fastest-growing applications...
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NIH awards $15m to support development of 3-D human tissue models
The NIH has announced 13 two-year awards totalling $15m, to develop 3-D microphysiological system platforms that model human disease...
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NGS In-Depth Focus 2017
Next-generation sequencing is a crucial part of the scientist's toolkit. This in-depth focus compares the strengths and weaknesses of a range of NGS technologies and examines the benefits and challenges of using it in infectious disease diagnosis...
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Mass spectrometry imaging in drug discovery
Mass spectrometry imaging allows direct measurement of the molecular composition of a sample. It can be used to image the spatial distribution of exogenous drugs and endogenous metabolites simultaneously over the surface of tissue sections or small biopsy, allowing new insights into both compound efficacy and safety during drug discovery.
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Expert view: Bridging the gap in users’ needs
The automated imaging and high-content imaging (HCI) markets are experiencing a widening dichotomy of users’ needs. Diverse hardware and software solutions are needed to bridge this divide...
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Imaging In-Depth Focus 2017
This In-Depth Focus explores current uses and future development in mass spectrometry imaging for bringing new drugs to market...
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DNA sequencing could open up new drug indications for rare cancers
A network of hospitals have systematically collected biopsies from metastatic cancer patients in order to create a global database...
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PerkinElmer launches new IVIS® Lumina™ S5 and Lumina X5 systems for high throughput in vivo imaging
Advanced 2D imaging and analysis help scientists rapidly trace anatomical and molecular aspects of diseases to advance drug discovery...
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Drug Target Review – Issue #3 2017
Included in this issue: The importance of industry partnerships; Calcilytics as potential novel therapeutic treatments to halt Alzheimer's disease; Accelerating neuroscience research with flow cytometry...