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Team identifies lead compound to potentially treat schistosomiasis
Researchers have found a quinoxaline-core containing, non-genotoxic lead compound that could treat schistosomiasis following optimisation.
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Lead compound for potential treatment of acute kidney injury identified
A new 6-chromanol-derived compound named SUL-138 has shown promise in animal models at treating acute kidney injury.
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“Overlooked” FAM72A gene shines light on antibody production
Scientists used a new screen to identify FAM72A as a cause of mutagenesis that affects antibody development in COVID-19 and cancer.
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Novel screening method identifies lead molecule for GPCR dimerisation
The new high-throughput screening method identified nine lead molecules for rhodopsin dimerisation that may lead to next-generation medicines.
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HAT proteins could unveil new cancer and Alzheimer’s treatments
The new study used cryo-electron microscopy to visualise the structure of a HAT protein and uncover compounds for drug development.
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“Sleeping” cancer cells could prevent tumour metastasis
A new study prevented the growth of metastatic tumours in mice by forcing cancer cells into a dormant state, pointing to novel treatments.
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Single molecule from plant used by Native Americans may treat diarrhoea
Scientists unveil the role of KCNQ2/3 using a functional screen of 40 native US plants and identify nine extracts that could treat diarrhoea.
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Rheumatoid arthritis discovery may lead to novel inflammation blockers
A new study links tumour necrosis factor seen in rheumatoid arthritis with T cell dysfunction, potentially leading to new therapies.
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Stress hormones linked to Crohn’s disease flare-ups
Removing stress hormones in mouse models restored proper function to immune cells and epithelial cells, pointing to new Crohn's treatments.
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Antihypertensive drugs could treat cerebral small vessel disease
The antihypertensive drug candesartan cilexetil reduced matrisomal protein accumulation in mice with cerebral small vessel disease.
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ABI3 gene may be the key to new Alzheimer’s disease therapies
The study found that deleting the ABI3 gene in mice increased plaques and inflammation in the brain, suggesting avenues for new treatments.
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Human iPSC-derived cardiomyocytes for cardiac proarrhythmic risk assessment
Following Drug Target Review's webinar supported by Eurofins, speaker Dr Verena Albert answers the questions posed by the audience during the live event.
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Scientists identify protein that prevents HSV-1 brain damage
Mammalian target of rapamycin complex 2 (mTORC2) was found to prevent brain damage in mice infected with herpes simplex virus 1 (HSV-1).
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Zaki syndrome: the newly uncovered condition and its potential cure
Dubbed 'Zaki syndrome', the condition affects prenatal development of several organs and was identified using whole genome sequencing.
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Scientists uncover key that permits hepatitis C entry into cells
A new study has identified a key protein on the surface of the hepatitis C virus that interacts with a receptor found on human cells.