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Phospholipid reactive T-cells could play a role in cancer
Phospholipid-reactive T-cells that are able to recognise phospholipids could help in treatments against cancer, autoimmune diseases and dyslipidemia...
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Drug Targets
A drug target is anything within a living organism to which a drug is directed and/or binds, resulting in a change in its behaviour or function.
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Omics-informed drug target discovery in combating emerging infectious diseases
The catastrophic consequences of ever-increasing rates of death from infectious diseases demands new experimental strategies for drug target selection and drug design. Over the last decade, the pharmaceutical industry has been wounded by several issues including failure of drug-development programmes, burgeoning cost of drug development, increasing regulatory control, lack of…
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Frizzled receptors could be drug targets for treating major diseases
Frizzled receptors, from the GPCR family, could soon be a target to treat numerous diseases such as cancer, fibrosis and CVD...
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Genes linked to dementia identified
Nanoscientists have identified genes that link to dementia, in the hope that future therapies could target these genes for positive results in patients...
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Targets In-Depth Focus 2018
In this supplement: Omics-informed drug target discovery in combating emerging infectious diseases, and self-delivering RNAi: paving the way for a new class of cancer immunotherapies.
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ZFP64 protein is key to deadly blood cancer MLL
ZFP64, an inconspicuous MLL fusion protein was found to be neccessary for the production of MLL proteins, and could be targeted to inprove outcomes of MLL...
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High-throughput platform could map cancer drug target activity
Manchester University researchers have developed a high-throughput platform to analyse and study a family of enzymes that are linked to cancer...
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Application note: Direct measurements of cellular metabolism for identification of mitochondrial drug targets
Drug target identification has a key role in the drug discovery value chain. A critical step in the development of pharmaceuticals is identifying the direct targets of potential drug candidates as well as distinguishing any secondary or off-target effects...
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Starving lung cancer could be an effective treatment
A recently discovered enzyme could lead to the development of a treatment where cancer cells are starved of 'food' provided by this protein...
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Supercoils in DNA could give insights to antibiotic drug development
DNA gyrase, a molecular machine used to prevent DNA from coiling, could be used to ensure bacterial DNA coils, reducing the risk of infection to humans...
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Cryoablation could treat low risk breast cancer
A study by Princeton Radiology researchers has found that cryoablation could be effective in targeting low risk breast cancer...
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slincR gene could shed light on chemical exposure effects in humans
The discovery of a new gene in zebrafish could lead to a better understanding of how exposure to chemicals leads to disease in humans...
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Drug Target Review – Issue 4 2018
In this issue: Omics-informed drug target discovery in combating emerging infectious diseases, measuring intracellular ATP levels to access compound-mediated cellular toxicity, and turning organoids into physiologically relevant high-content assays for drug discovery.
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Halting the spread of brain cancer
Mouse models used to show how convection enhanced delivery caused glioma cells to invade the rest of the brain could help to prevent this spread in future...
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Breast cancer recruits cells from bone marrow to boost growth
A study has shown that breast cancer uses stromal cells originally formed in bone marrow to boost their growth and metastasis of the cancer...
