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Majority of HIV persistence during ART due to infected cell proliferation
Study confirms biological mechanism responsible for latent HIV reservoirs; suggests strategies for a functional HIV cure...
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Drug Targets
A drug target is anything within a living organism to which a drug is directed and/or binds, resulting in a change in its behaviour or function.
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Vaccinia virus hijacks cellular movements to spread
To spread throughout the body, the vaccinia virus mimics the infected cells' own proteins enabling the cell to move around and spread...
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RIP1 kinase as a therapeutic target for pancreatic cancer
RIP1 has been shown to suppress the action of macrophages against the immune system and could be a potential therapeutic target for pancreatic cancer...
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Mouse model for diabetic kidney disease suggests role for immune and inflammatory pathways
Scientists have designed mice that successfully emulate a severe form of kidney damage in humans with diabetes, called diabetic nephropathy...
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Drug repurposing using off patent drugs as antifungals
Researchers have identified that Alexidine dihydrochloride can be used as a broad spectrum antifungal, and can also kill biofilms formed by these fungi...
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Gene responsible for hair loss discovered
The gene responsible for hair loss caused by the hypotrichosis simplex has been discovered by researchers at the University of Bonn...
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Scientists pinpoint mechanism by which mutant p53 protein promotes cancer
Scientists in Australia have discovered how the most important gene in preventing cancer, TP53, is hampered in its tumour-fighting efforts by mutant p53 proteins.
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Making old antibiotics work better using r8
A team of researchers have developed a way that could enhance the effect of current antibiotics, using a small molecular attachment called r8...
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Parasitic worm study predicts potential drug targets and drugs
The largest ever parasitic worm study has revealed nearly 1 million new genes, and has identified potential drug targets and drugs...
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Potential of gene therapy for neurological disorders
Gene therapy could be effective in numerous neurological conditions and could transform the lives of patients with these incurable diseases...
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NGLY1 protein identified as potential target for melanoma treatment
Scientists in the United States have inadvertently uncovered a promising treatment for melanoma that targets the NGLY1 gene.
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Heat-resistant enzymes for cost-effective drugs
The mechanisms and actions of heat-resistant enzymes are being investigated to aid better, more cost-effective drug design...
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Charles River to present collaborative methods at Neuroscience 2018
Charles River Laboratories International, Inc. (NYSE: CRL) announced that its team of neuroscience drug discovery experts will present 26 scientific posters, both independently and collaboratively with clients, at Neuroscience 2018, the 48th annual meeting of the Society for Neuroscience (SfN)...
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Water as a biomarker against cancer?
The Tn antigen appears in around 90 percent of cancers, and its structure is greatly affected by the addition of water molecules...
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Intriguing egg protein behaviour may shape fertility and cancer treatment
Scientists in the U.S. have published their findings about the behaviour of proteins in mouse eggs, projecting possible impacts on infertility and cancer treatment.
