news
Target for possible osteoarthritis treatment found in RORβ protein
A new study has revealed that activating the RORβ protein could lead to a possible treatment and prevention for osteoarthritis.
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Drug Targets
A drug target is anything within a living organism to which a drug is directed and/or binds, resulting in a change in its behaviour or function.
news
Scientists discover multiple pathways of the 5HT2a receptor activated by psychedelics
The new LSD-like compounds activated the 5HT2a receptor, a receptor stimulated by serotonin, without causing hallucinations.
podcasts
Episode 13 – Multiplexing with Dr Luke Gammon, Queen Mary University & Dr David Pointu, Leica Microsystems
Join our experts as they discuss the advantages of multiplexed imaging for a wide range of research and how this technique will develop in the future.
whitepaper
Application note: Fast-track antibody discovery: a high-throughput method for identifying and isolating rare secreting cells
Discover how picodroplet microfluidic technologies can identify and isolate 'hit' cells, quantify varying concentrations of antigen-specific antibodies and much more.
article
Targeting tau – chasing a treatment for Alzheimer’s
Alzheimer’s disease remains one of the largest challenges for the global ageing population. In this article, Victoria Rees, Editor of Drug Target Review, reviews some of the latest research, highlighting how progress has been made in understanding tau as well as how to potentially target this protein as a therapeutic strategy against…
news
Blocking trogocytosis improves ability of CAR T-cell therapy to treat cancer in mice
Researchers have found how tumours can avoid the immune system and cancer immunotherapies, including CAR T-cell therapies.
news
New machine learning technique to accelerate the process of drug screening
Researchers have developed a machine learning method to quantitatively analyse and compare microscopy images of proteins.
news
Scientists uncover new therapeutic target for treating colorectal tumours
New study has demonstrated that mice deficient in dendritic cell immunoreceptor are resilient against colitis and colonic tumour growth.
news
Promising developments in quest to design pan-coronavirus vaccine
Researchers have shown that a specific area of the SARS-CoV-2 spike protein is a promising target for a pan-coronavirus vaccine that could offer some protection against new virus variants, common colds, and help prepare for future pandemics.
article
The potential of Ayurvedic medicine
In a recent study, scientists have highlighted the possible use of South Asian medicine, specifically, Ayurvedic medicine, to treat type 2 diabetes. In this article, Drug Target Review dives into the study’s implications and what it means for the western world of drug discovery.
news
Chemokines work undercover as drivers of autoimmune disease
New research has uncovered a hitherto unknown mechanism whereby chemokines form DNA-bound nanoparticles that play a key role in autoimmune disorders.
news
Using organoids to identify drugs for autosomal dominant polycystic kidney disease
Scientists generated kidney organoids and used them to identify potential drugs to treat autosomal dominant polycystic kidney disease.
news
How EGF receptors influence cell growth
A new insight into the way the EGF receptor sends signals into cells could help researchers design new cancer drugs that target this protein.
news
A combination of nanotechnology, chemotherapy and a monoclonal antibody could treat glioblastoma
For the first time, researchers have tested a molecule that combines three distinct technologies against glioblastoma, the most aggressive type of brain cancer.
news
New brain mechanism involved in cocaine addiction has been identified
Researchers have found that blocking certain acetylcholine receptors in the lateral habenula made it harder to resist seeking cocaine in a rat model of addiction.
