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A drug target is anything within a living organism to which a drug is directed and/or binds, resulting in a change in its behaviour or function.
CAR T cells modified to recognise CEACAM7 were able to eliminate pancreatic ductal adenocarcinoma cells in a late-stage model without toxic effects on healthy tissue.
Researchers have developed a novel CAR T-cell therapy for neuroblastoma which uses gating to limit toxicity and T-cell exhaustion.
In this article, Drug Target Review’s Hannah Balfour discusses three of the latest developments in imaging for disease research and drug development.
A new study shows that upregulating the activity of the ACE2 signalling pathway in kidney cancer cells enhances the effects of clinically used treatments.
The discovery of an inflammatory pathway promoting brain ageing and cognitive decline could lead to new treatments for age-related conditions.
An antisense oligonucleotide has been developed by researchers to inhibit IRF4 as a potential strategy to treat multiple myeloma.
A single change to the structure of bacterial ribosomes prevents macrolide antibiotics from binding and killing the bacteria, according to a study.
Researchers have revealed how the most severe cases of G6PD deficiency occur, which could help scientists design new drugs for the disease.
Researchers show selectively activating androgen receptors could be an effective treatment for oestrogen receptor positive breast cancers.
Scientists have found that a new knee injection using nanomedicine could prevent the effects of osteoarthritis.
A study has said that restoring a particular protein's activity could be a new therapeutic strategy to treat glioblastoma.
The natural language processing model trained using viral protein sequence data was able to predict promising targets for vaccines against HIV, influenza and coronaviruses.
Researchers have isolated a compound from I. viscosa that kills the "brain-eating" amoebae from primary amoebic meningoencephalitis (PAM).
A better understanding of the role of four-stranded DNA (G-quadruplex) could enhance cancer therapeutics, said the developers of the probes.
Tests in Alzheimer's disease mouse models have shown that hydrogen sulphide can improve cognitive and motor function by 50 percent.
