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Exploration of autoimmune disease target tissues reveals novel drug targets
Researchers suggest that identifying new treatments for autoimmune diseases requires studying the immune system AND target tissues together.
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Drug Targets
A drug target is anything within a living organism to which a drug is directed and/or binds, resulting in a change in its behaviour or function.
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New drug target for non-small cell lung cancer identified
A new study has suggested that the enzyme GFPT2 could be a useful target for non-small cell lung cancer (NSCLC).
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NIK could be key to enhancing the effects of immunotherapy
Immunology study shows that NF-kappa B-inducing kinase (NIK) is critical to T cell metabolism and the antitumour immune response.
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Novel prostate cancer resistance mechanism could be a promising target
By inhibiting the activity of microRNA-194 (miR-194), scientists prevented prostate cancer cells from developing treatment resistance in vitro.
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Potential probiotic treatment identified for type 2 diabetes
Researchers have identified microbes that could affect the way a person metabolises glucose and lipids, leading to a potential treatment for type 2 diabetes.
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Brain injury may drive the development of cancer
A new study reveals that the healing process following a brain injury could initiate the growth of glioblastoma cancers.
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Novel bronchodilator could be used for control of asthma
Study identifies a promising new compound that can open constricted airways and could be a promising treatment for obstructive lung diseases.
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Activating STING enhances CAR T-cell activity in solid tumours, shows study
Researchers were able to eradicate breast cancer in mice when they combined CAR T cells with STING pathway agonists and immunotherapeutic antibodies.
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COVID-19 drug development based on boosting immunity
Baidyanath Dash explains the two requirements for COVID-19 drug development: killing the virus and boosting immunity.
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A computational effort to deciphering putative COVID-19 3C-like protease binders
Dr Isaac Karimi and his team explain how compounds to treat COVID-19 could be found in Kurdish ethnomedicine, selecting some plants for computational drug discovery.
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Unlocking the power of the microbiome in life sciences R&D
Anthony Finbow explains how applying microbiome-based evidence to disease modelling will enable researchers to devise more targeted treatments.
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Potential therapeutic target identified for stomach cancer
A team has shown that removing the inflammatory signalling protein TNF in a laboratory model prevented stomach cancers from becoming severe.
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Researchers reveal protein function that could improve chemotherapy
Scientists have found that the RFWD3 protein could play a role in recruiting DNA key repair and signalling factors, impacting chemotherapy.
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Human 3D cell-based systems to research gout: drug discovery for a neglected disease
In this article Andrew Nyborg from Horizon Therapeutics discusses why researchers are taking a second look at gout and how they are modelling the condition, which is unique to humans.
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New treatment approach kills lymphoma while sparing healthy cells in mice
By combining natural killer cells with a new molecule called Sialyl-Lewis X, researchers were able to treat lymphoma in mice.
