news Studies in mice reveal link between obesity and tumour growth 10 December 2020 | By Victoria Rees (Drug Target Review) New research has provided a metabolic atlas for insights into obesity and tumours' ability to hide from the immune system.
news Novel target could treat both SARS-CoV-2 and other coronaviruses 10 December 2020 | By Hannah Balfour (Drug Target Review) Scientists shows targeting cholesterol or phosphatidylinositol phosphate (PIP) could be a promising strategy to combat multiple coronaviruses.
news Non-hallucinogenic version of ibogaine could treat addiction and depression 10 December 2020 | By Victoria Rees (Drug Target Review) A non-hallucinogenic version of the psychedelic drug ibogaine could treat psychiatric disorders, pre-clinical trials have shown.
article Trends in pancreatic cancer literature – findings from Elsevier 9 December 2020 | By Victoria Rees (Drug Target Review) In a new report, Elsevier describes how it used text mining to reveal the top trends in pancreatic cancer research – this article outlines the findings.
news Biomarker for blood vessel damage found in children with SARS-CoV-2 9 December 2020 | By Victoria Rees (Drug Target Review) Elevated levels of a biomarker related to blood vessel damage have been found in all children with SARS-CoV-2 infection.
news Role of gene in metastasis of brain cancer revealed 9 December 2020 | By Victoria Rees (Drug Target Review) Researchers have shown how increased YTHDF3 expression correlates with brain cancer metastases, making it a target for the condition.
news Inhibiting cadherin 11 significantly increases survival of mice with pancreatic cancer 9 December 2020 | By Hannah Balfour (Drug Target Review) Mice treated with a small molecule inhibitor of cadherin 11 (CDH11) had reduced pancreatic cancer growth and increased survival time.
news Novel target for pulmonary fibrosis identified using tissue from COVID-19 patients 7 December 2020 | By Hannah Balfour (Drug Target Review) Study suggests reducing the expression of the methyl-CpG-binding domain 2 (MBD2) protein on macrophages could be a viable therapeutic strategy for lung fibrosis.
news Oral drug blocks SARS-CoV-2 transmission in ferrets, researchers find 4 December 2020 | By Victoria Rees (Drug Target Review) A team has found that their drug Molnupiravir (MK-4482/EIDD-2801) acts as an antiviral against SARS-CoV-2 in pre-clinical studies.
news Microscopy reveals four classes of SARS-CoV-2 neutralising antibodies 4 December 2020 | By Hannah Balfour (Drug Target Review) Researchers show that neutralising antibodies targeting the SARS-CoV-2 Spike protein have four distinct structures.
news New insulin molecule can self-regulate blood sugar in rats 4 December 2020 | By Victoria Rees (Drug Target Review) Researchers have developed a novel insulin molecule that responds to glucose levels in the blood sugar of rats, which they say could help patients with type 1 diabetes.
news A novel CAR T-cell therapy for type 1 diabetes 4 December 2020 | By Hannah Balfour (Drug Target Review) Researchers show how genetically engineered five-module chimeric antigen receptor (5MCAR) T cells can be directed to destroy T cells causing autoimmune diseases.
news Researchers provide new insights into SARS-CoV-2 lung pathology 3 December 2020 | By Hannah Balfour (Drug Target Review) The new study shows how SARS-CoV-2 significantly remodels cellular processes in just an hour and identifies potential drug targets and therapeutics for COVID-19.
news Mitochondrial protein revealed as target for cardiovascular disease 3 December 2020 | By Victoria Rees (Drug Target Review) According to new research, the protein ALDH4A1 is a possible therapeutic target and diagnostic biomarker for cardiovascular disease.
article Combining deep computational learning and synthetic biology 3 December 2020 | By Victoria Rees (Drug Target Review) Dr Diogo Camacho from the Wyss Institute at Harvard discusses new research into using machine learning algorithms to analyse RNA sequences and reveal potential drug targets.
