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COVID-19 update: funding for treatments and vaccines
Drug Target Review rounds up the latest announcements regarding funding for research into COVID-19 treatments and vaccines.
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Drug Targets
A drug target is anything within a living organism to which a drug is directed and/or binds, resulting in a change in its behaviour or function.
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Novel CAR T-cell immunotherapy eradicates solid tumours in mice
Researchers have developed a new CAR T-cell therapy that targets an antigen called glycipan-1 (GPC1), showing efficacy at fighting solid tumours in mice.
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Novel tuberculosis transport protein could be target of new treatments
Cryogenic electron microscopy revealed that the vitamin B12 transporter on Mycobacterium tuberculosis acts like a non-selective sluice, transporting both the vitamin and antibiotics.
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Free access to AI Clinical Research Navigator tool for COVID-19 researchers
In light of the COVID-19 pandemic, the creators of the Clinical Research Navigator (CRN) tool have offered free access to their system for biomedical researchers.
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Researchers identify target to improve dendritic cell ability to fight tumours
A new study has shown that the role of T cell-suppressing dendritic cells can be reversed in mice, indicating that immunotherapies could be improved with this method.
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Nafamostat inhibits SARS-CoV-2 infection, preventing COVID-19 transmission
Researchers have demonstrated that Nafamostat mesylate (Fusan) can inhibit SARS-CoV-2 Spike protein-initiated membrane fusion at concentrations likely achievable and safe in patients.
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HTS used to reveal anticancer properties of cannabinoid combinations
Researchers have used high-throughput screening to discover the best combinations of purified cannabinoids against gastrointestinal cancer cells.
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TAp63, miRNAs and AURKA: novel cutaneous squamous cell carcinoma drug targets
The TAp63 tumour suppressor protein, two micro RNAs (miRNAs) and the AURKA gene can all suppress cutaneous squamous cell carcinoma (cuSCC) development, find researchers.
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Researchers optimise PROTAC technology to dispose of cancer proteins
Researchers have optimised PROTAC substances to degrade and dispose of proteins that support cancers, by customising their structure and selecting the best ligases.
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Novel antiviral compound proposed as COVID-19 therapeutic
A molecule called BOLD-100, developed to fight cancer, has been suggested as a therapeutic to combat the COVID-19 coronavirus due to its antiviral properties.
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Genetic deletion permanently prevented type 1 diabetes development in mice
Researchers observed that deleting the IRE1-alpha gene caused beta cells to de-differentiate and then re-differentiate in mice, preventing immune system auto-activation.
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Host pathways in coronavirus replication and COVID-19 pre-clinical drug target identification using proteomic and chemoinformatic analysis
The identification of host dependency factors mediating virus infection may provide key insights into effective molecular targets for developing broadly acting antiviral therapeutics against SARS-CoV-2 and other deadly coronavirus strains. Here, Joseph Steward highlights key findings of recent research.
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The latest developments in diabetes drug discovery
Several new advances have been made in the field of drug discovery for diabetes – here, three of the most recent have been rounded up.
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‘Cell-projection pumping’ presents new cancer target, say researchers
A new discovery about how cancer cells exchange contents with fibroblasts presents a new oncologic drug target, according to the researchers.
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Enzyme vital for sperm formation potential target for male infertility
Researchers have identified an enzyme required for the formation of sperm and chromosomal pairing, which they say could be a target to treat male infertility.