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Gene therapy could cure Danon disease, life-threatening genetic condition
Researchers have shown a gene therapy to correct the genetic mutation that causes Danon disease is successful in pre-clinical trials.
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Drug Targets
A drug target is anything within a living organism to which a drug is directed and/or binds, resulting in a change in its behaviour or function.
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Ion channel ball-and-chain mechanism imaged after decades of attempts
Scientists have imaged the ball-and-chain mechanism using cryogenic electron microscopy and hope their work could be applied in the design of novel therapeutics.
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Artificial binding protein could be developed into a novel anti-viral or cancer therapy
Scientists have created an artificial protein able to recognise and bind cell surface carbohydrates with high affinity and selectivity.
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Interleukin-2 interactions revealed by researchers to aid in drug design
Using nuclear magnetic resonance spectroscopy, a study has shown that IL-2 can stimulate both effector T cells and regulatory T cells by adopting different structural forms.
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CRISPR RNA-targeted genetic screen could be used for COVID-19 therapy
A new Cas13 RNA screen has been used to establish guide RNAs for the COVID-19 coronavirus and human RNA segments which could be used in vaccines, therapeutics and diagnostics.
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Collaboration to co-develop antibody products for treating COVID-19
AbCellera and Eli Lilly have announced their partnership to develop, manufacture and distribute antibody treatments for the COVID-19 coronavirus.
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Drug candidate stops tumour growth with little toxicity in mice
A star-shaped molecule along with a modified platinum drug have demonstrated success at combatting tumours with few toxic effects in mice.
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Inhibiting the epichaperome to combat Alzheimer’s disease
Pre-clinical studies demonstrate that inhibiting the ’epichaperome’ can restore neural networks to normal levels. Dr Barbara Wallner at Samus Therapeutics explains how targeting the epichaperome could work as a potential treatment for Alzheimer’s and other neurodegenerative diseases.
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Inactivated human muscarinic receptors used in new screening method
Researchers have developed a new screening technique by inactivating the molecular structure of the human muscarinic receptor, allowing them to test potential drugs.
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3D visualisation of COVID-19 surface released for researchers
A new 3D model of the surface of the coronavirus COVID-19 has been released, to aid researchers in the development of a treatment.
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New optical technique affords unique insight into blood cell development
Scientists in Hong Kong have developed a novel optical technique that facilitates accurate tracking of hemogenic endothelium cells in zebrafish embryos, providing new insights into the mechanisms of blood formation and potential new understanding of diseases such as leukaemia.
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Researchers work to create a COVID-19 viral epitope map
The team used data from SARS-CoV to identify possible viral epitopes that vaccines could include to stimulate an immune response.
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Copper ions could be key to blocking cancer metastasis
Researchers have identified that copper ions and their protein transporters, such as Atox1, are key to cancer cell movement and could be targeted by therapies.
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Virtual reality could be used to design new drugs, say researchers
Researchers have used virtual reality (VR) to control how drugs bind to their protein targets, which they say could be useful for designing new treatments.
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Exploring future spinal cord injury therapies
Drug Target Review explores five of the latest research developments in the field of spinal cord injury (SCI) repair.